122001-34-7Relevant academic research and scientific papers
2-aminobenzimidazole derivatives strongly inhibit and disperse Pseudomonas aeruginosa biofilms
Frei, Reto,Breitbach, Anthony S.,Blackwell, Helen E.
, p. 5226 - 5229 (2012)
Bacterial biofilms are exceptionally difficult to clear using traditional antibiotics and constitute a significant health threat. 2-Aminobenzimidazole derivatives (see scheme) are capable of strongly inhibiting the growth of and dispersing Pseudomonas aeruginosa biofilms. These molecules were found to modulate quorum sensing in reporter strains, and represent some of strongest P. aeruginosa biofilm inhibitors known. Copyright
Inhibition and Dispersion of Bacterial Biofilms with 2-Aminobenzimidazole Derivatives
-
Paragraph 0194; 0195; 0196; 0197; 0198; 0199; 0200, (2013/06/05)
Compounds described herein inhibit biofilm formation or disperse pre-formed biofilms of Gram-negative bacteria. Biofilm-inhibitory compounds can be encapsulated or contained in a polymer matrix for controlled release. Coatings, films, multilayer films, hydrogels, microspheres and nanospheres as well as pharmaceutical compositions and disinfecting compositions containing biofilm-inhibitory compounds are also provided. Methods for inhibiting formation of biofilms or dispersing already formed biofilms are provided. Methods for treating infections of gram-negative bacteria which form biofilms, particularly those of Pseudomonas and more particularly P. aeruginosa.
