122001-44-9

Upstream product

• 15081-13-7 3-methyl-4,4-bis-methylsulfanyl-but-3-en-2-ol 
• 178320-76-8 7,7-bis(methylthio)-6-methyl-1-phenyl-2,4,6-heptatriene-1-one 
• 17649-87-5 3-methyl-4,4-bis(methylthio)but-3-en-2-one 
• 67-56-1 methanol 
• 14371-10-9 (E)-3-phenylpropenal 
• 129144-90-7 2-methyl-4-(triphenyl-λ⁵-phosphoranylidene)but-2-enoic acid methyl ester 
• 129611-83-2 7,7-bis(methylthio)-6-methyl-2,4,6-heptatrienal 
• 129611-81-0 5,5-bis(methylthio)-4-methyl-2,4-pentadienal 

Relevant academic research and scientific papers

A new 1,5- to 1,11-carbonyl transposition protocol involving ketene dithioacetal chemistry: An efficient polyene synthesis

An efficient strategy for alternative 1,5-, 1,7-, 1,9- and 1,11- carbonyl transposition has been developed via 1,2-reductive or alkylative addition to 5,5-bis(methylthio)-2,4-pentadienals 3a-b, 7,7-bis(methylthio)-2,4,6-heptatrienones 5,9,9-bis(methylthio)-2,4,6,8-nonatetraenones 8 and 11,11-bis(methylthio)-2,4,6,8,10-undecapentaenones 11 followed by BF3,Et2O induced methanolysis of the resulting carbinols to the corresponding polyene esters. The synthesis of the novel polyene aldehydes 3a-b, 7a-b, 10b and polyenones 5, 8, 11 precursors has also been described following iterative Vielsmeier-Haack reaction and aldol condensation.