1220120-60-4Relevant academic research and scientific papers
Hydrosilanes are not always reducing agents for carbonyl compounds, II: Ruthenium-catalyzed deprotection of tert-butyl groups in carbamates, carbonates, esters, and ethers
Hanada, Shiori,Yuasa, Akihiro,Kuroiwa, Hirotaka,Motoyama, Yukihiro,Nagashima, Hideo
supporting information; experimental part, p. 1021 - 1025 (2010/04/27)
Hydrosilanes act as a reagent to cleave the C-O bond of OtBu groups in carbamates, carbonates, esters, and ethers by catalysis of a triruthenium cluster. The reaction offers a novel deprotection method, for OiBu groups under neutral conditions, showing unique selectivities that have never been accomplished with conventional Bronsted or Lewis acidic promoters. Possible mechanisms for C-O cleavage are discussed on the basis of NMR spectroscopic analysis.
