1220122-24-6Relevant academic research and scientific papers
Silica supported polyphosphoric acid (PPA-SiO2): An efficient and reusable heterogeneous catalyst for the one-pot synthesis of α-amino phosphonates
Maghsoodlou, Malek Taher,Habibi Khorassani, Sayyed Mostafa,Heydari, Reza,Hazeri, Nourollah,Sajadikhah, Seyed Sajad,Rostamizadeh, Mohsen,Keishams, Leila
, p. 565 - 570 (2010)
An efficient green protocol is described for the preparation of α-amino phosphonates, employing a one-pot three-component condensation reaction between aldehydes, amines, and trialkyl phosphites in the presence of PPA-SiO2 under solvent-free conditions at 80 ° C. The present procedure offer advantages such as high to excellent yields, short reaction time, inexpensiveness, recovery, and reusability of catalyst. tuebitak.
Magnetic Fe3O4 nanoparticle-supported phosphotungstic acid as a recyclable catalyst for the kabachnik-fields reaction of isatins, imines, and aldehydes under solvent-free conditions
Nazish, Mohd,Saravanan,Khan, Noor-Ul H.,Kumari, Prathibha,Kureshy, Rukhsana I.,Abdi, Sayed H. R.,Bajaj, Hari C.
, p. 1753 - 1760 (2015/02/02)
Magnetic-nanoparticle-supported phosphotungstic acid has been used to efficiently catalyze the hydrophosphonylation reaction of isatins, imines, and aldehydes using dimethyl and diethyl phosphite as a nucleophile to give the corresponding α-hydroxy and α-amino phosphonates in excellent yields for a wide range of substrates. The reaction conditions were simple, green, and efficient. The catalyst was recycled up to five times with retention of its activity. Based on the NMR spectroscopy studies, a probable catalytic cycle was proposed.
A green protocol for one-pot three-component synthesis of α-amino phosphonates catalyzed by succinic acid
Hazeri, Nourallah,Maghsoodlou, Malek Taher,Habibi-Khorassani, Sayyed Mostafa,Aboonajmi, Jasem,Lashkari, Mojtaba,Sajadikhah, Seyed Sajad
, p. 1781 - 1788 (2014/05/06)
A simple, efficient, and general method has been developed for the one-pot, three-component synthesis of α-amino phosphonates from a condensation reaction of trialkyl phosphite, aldehydes, and amines in the presence of a catalytic amount of succinic acid (8.5 mol %) (for the first time) under solvent-free conditions. The advantages of this protocol are excellent yields, short reaction time, mild reaction conditions, higher availability, low costs, more environmentally friendly, lack of need for column chromatography and simple work-up procedure. Graphical Abstract: [Figure not available: see fulltext.]
