122019-81-2Relevant academic research and scientific papers
Synthesis of enol lactones via Cu(I)-catalyzed intramolecular O-vinylation of carboxylic acids
Sun, Changhul,Fang, Yewen,Li, Shuang,Zhang, Yue,Zhao, Qlwu,Zhu, Shana,Li, Chaozhong
supporting information; experimental part, p. 4084 - 4087 (2009/12/06)
With the catalysis of Cul/trans-W,W-dimethylcyclohexane-1,2-diamine, a number of carboxylic acids underwent efficient intramolecular O-vinylation with vinyl bromides leading to the synthesis of the corresponding five- and six-membered enol lactones. The same catalytic system also led to the efficient cycloisomerization of alkynoic acids.
Resolution and Determination of the Absolute Stereochemistry of α- and β-Aryl-Substituted γ-Methylenevalerolactones, Alternate Substrate Inhibitors for Serine Proteases
Baek, Du-Jong,Daniels, Scott B.,Reed, Peter E.,Katzenellenbogen, John A.
, p. 3963 - 3972 (2007/10/02)
To study the enantioselectivity of alternate substrate inhibition of chymotrypsin by chiral α- and β-arylsubstituted enol lactones, we have prepared four of these lactones in homochiral form: 3-phenyl-6-methylenetetrahydro-2-pyranone (αPh6H, IIa), 3-(1-na
