88071-01-6Relevant academic research and scientific papers
Haloenol pyranones and morpholinones as antineoplastic agents of prostate cancer
Mock, Jason N.,Taliaferro, John P.,Lu, Xiao,Patel, Sravan Kumar,Cummings, Brian S.,Long, Timothy E.
scheme or table, p. 4854 - 4858 (2012/08/13)
Haloenol pyran-2-ones and morpholin-2-ones were synthesized and evaluated as inhibitors of cell growth in two different prostate human cancer cell lines (PC-3 and LNCaP). Analogs derived from l- and d-phenylglycine were found to be the most effective antagonists of LNCaP and PC-3 cell growth. Additional studies reveal that the inhibitors induced G2/M arrest and the (S)-enantiomer of the phenylglycine-based derivatives was a more potent inhibitor of cytosolic iPLA2β.
