122035-83-0Relevant academic research and scientific papers
Nickel-Catalyzed Direct Trifluoroethylation of Aryl Iodides with 1,1,1-Trifluoro-2-Iodoethane via Reductive Coupling
Li, Han,Sheng, Jie,Liao, Guang-Xu,Wu, Bing-Bing,Ni, Hui-Qi,Li, Yan,Wang, Xi-Sheng
, p. 5363 - 5367 (2020)
A nickel-catalyzed direct trifluoroethylation of aryl iodides with an industrial raw material CF3CH2I has been developed, demonstrating high efficiency, excellent functional-group compatibility, especially with large sterically hindered groups. The key to success is the combination of nickel with readily available nitrogen and phosphine ligands. The powerful potential of this strategy is further demonstrated by the late-stage modification of several derived bioactive molecules. (Figure presented.).
Alkylations of Arylboronic Acids including Difluoroethylation/Trifluoroethylation via Nickel-Catalyzed Suzuki Cross-Coupling Reaction
Zhang, Xiaofei,Yang, Chunhao
supporting information, p. 2721 - 2727 (2015/09/01)
An efficient alkylation method of functionalized alkyl halides under mild nickel-catalyzed C(sp3)-(sp2) Suzuki cross-coupling conditions is described. The features of this approach are excellent functional group compatibility, low cost nickel catalyst, and the use of a mild base. This is also the first successful example of the nickel-catalyzed direct 2,2-difluoroethylation or 2,2,2-trifluoroethylation of aryl-/heteroarylboronic acids.
REDUCTION OF THE 1-(4-THIOMETHYLPHENYL)-2,2,2-TRIFLUOROETHYL CARBOCATION BY SODIUM SULFITE
Richard, John P.
, p. 23 - 26 (2007/10/02)
The rate of reaction of sodium sulfite with 1-(thiomethylphenyl)-2,2,2-trifluoroethyl bromide in 20percent acetonitrile in water is kinetically zero-order in sulfite anion and at 0.27 M SO32- the reaction gives a 0.67:0.15:0.18 ratio of the C-1 sulfite adduct, the water adduct and the novel reduction product 1-(4-thiomethylphenyl)-2,2,2-trifluoroethane, respectively.
