1220352-85-1

Basic information

• Product Name: C₁₈H₁₆ClN₅OS₂
• CAS NO: 1220352-85-1
• Molecular Weight: 417.943
• Mol File: 1220352-85-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₆ClN₅OS₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₆ClN₅OS₂(1220352-85-1)
• EPA Substance Registry System: C₁₈H₁₆ClN₅OS₂(1220352-85-1)

Safety Data

• Hazardous Substances Data: 1220352-85-1(Hazardous Substances Data)

Upstream product

• 95-53-4 o-toluidine 
• 99-91-2 para-chloroacetophenone 
• 614-78-8 o-tolylthiourea 
• 2103-99-3 4-(4-chlorophenyl)-2-thiazolamine 
• 126751-17-5 2-(Carboethoxy)amino-5-(4-chlorophenyl)thiazole 
• 614-10-8 4-(2-methylphenyl)-3-thiosemicarbazide 

Downstream Products

• 1223570-11-3 3-[4-(4-chlorophenyl)-1,3-thiazol-2-ylamino]-4-(2-methylphenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thione 
• 1220352-65-7 N-[4-(4-chlorophenyl)-thiazol-2-yl]-N'-(2-methylphenyl)-[1,3,4]thiadiazole-2,5-diamine 

Relevant articles and documents

Synthesis, anticonvulsant and toxicity screening of thiazolyl-thiadiazole derivatives

Various thiazole-substituted thiadiazole derivatives (7a-t) were designed and synthesized using substituted acetophenones and substituted anilines as starting materials. Thiazole and thiadiazole moieties being anticonvulsants were clubbed together to get the titled compounds and their in vivo anticonvulsant screening were performed by two most adopted seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). Three compounds 7i, 7l and 7n were found to be potent in both the screens with comparable ED50 and better TD50 values than some standard drugs. These compounds were also found to exert lesser toxic effects on liver.