1223570-11-3

Basic information

• Product Name: 3-[4-(4-chlorophenyl)-1,3-thiazol-2-ylamino]-4-(2-methylphenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thione
• CAS NO: 1223570-11-3
• Molecular Weight: 399.928
• Mol File: 1223570-11-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[4-(4-chlorophenyl)-1,3-thiazol-2-ylamino]-4-(2-methylphenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(4-chlorophenyl)-1,3-thiazol-2-ylamino]-4-(2-methylphenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thione(1223570-11-3)
• EPA Substance Registry System: 3-[4-(4-chlorophenyl)-1,3-thiazol-2-ylamino]-4-(2-methylphenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thione(1223570-11-3)

Safety Data

• Hazardous Substances Data: 1223570-11-3(Hazardous Substances Data)

Upstream product

• 1220352-85-1 C₁₈H₁₆ClN₅OS₂ 

Relevant articles and documents

Triazole incorporated thiazoles as a new class of anticonvulsants: Design, synthesis and in vivo screening

Various 3-[4-(substituted phenyl)-1,3-thiazol-2-ylamino]-4-(substituted phenyl)-4,5-dihydro-1H-1,2,4-triazole-5-thiones (7a-t) were designed keeping in view the structural requirements suggested in the pharmacophore model for anticonvulsant activity. Thiazole and triazole moieties being anticonvulsants were clubbed together to get the titled compounds and their in vivo anticonvulsant screening were performed by two most adopted seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). Two compounds 7d and 7f showed significant anticonvulsant activity in both the screens with ED50 values 23.9?mg/kg and 13.4?mg/kg respectively in MES screen and 178.6?mg/kg and 81.6?mg/kg respectively in scPTZ test. They displayed a wide margin of safety with Protective index (PI), median hypnotic dose (HD50) and median lethal dose (LD50) much higher than the standard drugs.