122044-76-2

Upstream product

• 56917-71-6 5-trimethylsilyl-2-cyclohexanone 
• 3277-89-2 phenethylmagnesium bromide 
• 116428-42-3 [2-((1R,5R)-5-Trimethylsilanyl-3-trimethylsilanyloxy-cyclohex-2-enyl)-ethyl]-benzene 
• 18407-84-6 1-methoxy-3,6-bis(trimethylsilyl)cyclohexa-1,4-diene 
• 56917-70-5 5-(trimethylsilyl)cyclohex-3-enone 
• 122047-05-6 [2-((1R,5R)-5-Trimethylsilanyl-3-trimethylsilanyloxy-cyclohex-2-enyl)-ethyl]-benzene 

Downstream Products

• 111748-85-7 4-(2-phenylethyl)-4,5-dihydro-3H-furan-2-one 
• 118527-89-2 3-Phenethyl-hex-5-enoic acid methyl ester 
• 118527-96-1 5-Oxo-3-phenethyl-hexanoic acid methyl ester 
• 118527-82-5 (4R,6S)-4-Phenethyl-6-trimethylsilanyl-oxepan-2-one 

Relevant academic research and scientific papers

SYNTHESIS OF (+)-α-CURCUMENE, (+)-CURCUMONE AND (-)-METHYL CITRONELLATE STARTING FROM OPTICALLY PURE 5-TRIMETHYLSILYL-2-CYCLOHEXENONE

1,4-addition of Grignard reagents in the presence of chlorotrimethylsilane to 5-trimethylsilyl-2-cyclohexanone (1) proceeded in a highly diastereoselective manner to give trans adducts in high yields. (+)-α-Curcumene, (+)-curcumone and (-)-methyl citronellate were synthesized starting from optically pure 1.

Synthesis of Chiral 5-Substituted Cyclohex-2-enones from 5-Trimethylsilylcyclohex-2-enone

Optically active and racemic-5-substituted cyclohex-2-enones were synthesized from 5-trimethylsilylcyclohex-2-enone.

(R)- AND (S)-5-TRIMETHYLSILYL-2-CYCLOHEXENONE: A VERSATILE CHIRAL SOURCE FOR THE SYNTHESIS OF OPTICALLY ACTIVE CYCLOHEXANONE DERIVATIVES

5-Trimethylsilyl-2-cyclohexenone was synthesized from anisole and was successfully resolved to the optically pure form utilizing kinetic resolution method of the reaction with thiol in the presence of cinchonidine. (+)-α-curcumene was synthesized from (R)