122058-04-2Relevant academic research and scientific papers
THE REACTION OF ETHYL-FORMIMIDATE WITH GRIGNARD REAGENTS: A NEW APPROACH TO ELECTROPHILIC AMINATION
Zawadzki, Stefan
, p. 263 - 268 (2007/10/02)
Addition of Grignard reagents to ethyl-N-(diethoxyphosphoryl)formimidate, 3 followed by aqueous workup and treatment of the resultant diethyl phosphoramidates with p-toluenesulfonic acid in ethanol gives, depending upon the organomagnesium reagent used, the corresponding tosylates of primary or secondary amines in moderate to good yields.The diethoxyphosphoryl moiety remains unchanged upon treatment of 3 with Grignard reagents.Key words: Diethyl-(N-alkylphosphoramidates); Grignard reagents; ammonium tosylates; substitution-addition; substitution-reduction; electrophilic amination.
