1220596-13-3Relevant academic research and scientific papers
COMPOUNDS USEFUL AS CHEMOKINE RECEPTOR ANTAGONISTS
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Page/Page column 51-52, (2011/06/16)
The present invention relates to a compound having the general Formula I: Formula I wherein the variables are as defined in the specification. The present invention further relates to pharmaceutical compositions comprising these compounds and to their use
CYCLIC UREAS USEFUL AS HIV INHIBITORS
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Page/Page column 41, (2011/06/16)
The present invention relates to a compound having the general Formula (I), wherein the variables are as defined in the specification. The present invention further relates to pharmaceutical compositions comprising these compounds and to their use in ther
Direct synthesis of Cbz-protected (2-amino)-6-(2-aminoethyl)pyridines
Roy, Sudipta,Zych, Andrew J.,Herr, R. Jason,Cheng, Cliff,Shipps Jr., Gerald W.
experimental part, p. 1973 - 1979 (2010/04/24)
A novel series of (2-amino)-6-(2-aminoethyl)pyridines were prepared by a convenient Suzuki-Miyaura coupling approach from 2-amino-6-bromopyridines. Benzyl vinylcarbamate was first treated with 9-BBN followed by aqueous NaOH and then the appropriate bromopyridine precursors were added into the mixture. The mixture was finally heated in presence of a palladium catalyst to provide the corresponding products in overall high yields. The procedure is extended to the preparation of related pyrazine and pyrimidine compounds as well as (2-amido)- and (2-alkoxy)-6-(2-aminoethyl)pyridines.
COMPOUNDS USEFUL AS HIV BLOCKERS
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Page/Page column 106, (2010/06/15)
The present invention relates to a compound having the general Formula (I): wherein the variables are as defined in the specification. The present invention further relates to pharmaceutical compositions comprising these compounds and to their use in therapy, in particular for the treatment or prevention of chemokine-mediated disorders such as HIV infection.
