1220690-23-2Relevant academic research and scientific papers
Chelator fragment libraries for targeting metalloproteinases
Agrawal, Arpita,Johnson, Sherida L.,Jacobsen, Jennifer A.,Miller, Melissa T.,Chen, Li-Hsing,Pellecchia, Maurizio,Cohen, Seth M.
experimental part, p. 195 - 199 (2010/11/04)
(Chemical Equation Presented) A chelator fragment library based on a variety of metal binding groups was screened against a metalloproteinase. Lead hits were identified and an expanded library of select compounds was synthesized, resulting in numerous high-affinity hits against several metalloprotein targets. The findings clearly demonstrate that chelators can be used to generate libraries suitable for fragment-based lead design (FBLD) directed at important metalloproteins.
