122080-91-5

Upstream product

• 122081-15-6 3-{[(4-methylphenyl)sulfonyl]amino}-1-pyrrolidinylpropan-1-one 
• 61341-03-5 N-(toluene-4-sulfonyl)-β-alanyl chloride 
• 106-95-6 allyl bromide 
• 98-59-9 p-toluenesulfonyl chloride 
• 42908-33-8 3-{[(4-methylphenyl)sulfonyl]amino}propanoic acid 

Downstream Products

• 122080-99-3 (cis)-3-[(4-methylphenyl)sulfonyl]-3-azabicyclo[3.2.0]heptan-6-one 
• 122081-06-5 (1S,5R)-3-(Toluene-4-sulfonyl)-3-aza-bicyclo[3.1.1]heptan-6-one 
• 122080-99-3 3-[(4-methylphenyl)sulfonyl]-3-azabicyclo[3.2.0]heptan-6-one 
• 663172-78-9 tert-butyl 6-hydroxy-3-azabicyclo[3.2.0]heptane-3-carboxylate 

Relevant academic research and scientific papers

TRICYCLIC GYRASE INHIBITORS

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

Intramolecular [2 + 2] cycloadditions of keteniminium salts derived from α- and β-amino acids. A route to azabicyclic ketones

Unsaturated N-tosylaminoketeniminium salts generated in situ from α- and β-aminoamides readily underwent intramolecular [2 + 2]cycloadditions to give azabicyclic ketones in good yields.