42908-33-8

Basic information

• Product Name: 3-(TOLUENE-4-SULFONYLAMINO)-PROPIONIC ACID
• Synonyms: beta-alanine, N-[(4-methylphenyl)sulfonyl]-;N-[(4-methylphenyl)sulfonyl]-beta-alanine;3-[(4-methylphenyl)sulfonylamino]propanoic acid;3-[(4-methylphenyl)sulfonylamino]propionic acid;Propionic acid, 3-(4-tolylsulfonylamido)-;3-((4-methylphenyl)sulfonamido)propanoicacid
• CAS NO: 42908-33-8
• Molecular Formula: C₁₀H₁₃NO₄S
• Molecular Weight: 243.28
• Mol File: 42908-33-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 442.3°C at 760 mmHg
• Flash Point: 221.3°C
• Appearance: /
• Vapor Pressure: 1.34E-08mmHg at 25°C
• CAS DataBase Reference: 3-(TOLUENE-4-SULFONYLAMINO)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(TOLUENE-4-SULFONYLAMINO)-PROPIONIC ACID(42908-33-8)
• EPA Substance Registry System: 3-(TOLUENE-4-SULFONYLAMINO)-PROPIONIC ACID(42908-33-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 42908-33-8(Hazardous Substances Data)

Usage

General Description

3-(toluene-4-sulfonylamino)-propionic acid is a chemical compound with the molecular formula C11H13NO4S. It is a derivative of toluene and is used as a building block in the synthesis of various pharmaceuticals and organic compounds. 3-(TOLUENE-4-SULFONYLAMINO)-PROPIONIC ACID has a sulfonamide group attached to the toluene ring, which gives it unique characteristics and reactivity. It is commonly used as a reagent in organic synthesis and medicinal chemistry, and its derivatives have potential applications as drugs and bioactive compounds.

InChI:InChI=1/C10H13NO4S/c1-8-2-4-9(5-3-8)16(14,15)11-7-6-10(12)13/h2-5,11H,6-7H2,1H3,(H,12,13)/p-1

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 3634-89-7 N-(p-toluenesulfonyl)aziridine 
• 124-38-9 carbon dioxide 
• 50487-71-3 4-methyl-N-(2-propenyl)benzenesulfonamide 
• 718633-51-3 N-1-(3-oxopropyl)-4-methyl-1-benzenesulfonamide 
• 107-95-9 3-amino propanoic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 107-94-8 chloropropionic acid 
• 2619-16-1 N,N-bis[(2-cyanoethyl)]-4-methylbenzenesulfonamide 

Downstream Products

• 78221-08-6 N-(2-Imino-thiazolo[4,5-b]quinoxalin-3-yl)-3-(toluene-4-sulfonylamino)-propionamide 
• 1027835-82-0 C₂₄H₃₂N₄O₃S 
• 122081-15-6 3-{[(4-methylphenyl)sulfonyl]amino}-1-pyrrolidinylpropan-1-one 
• 68768-96-7 (3aS)-3c-[N-(toluene-4-sulfonyl)-β-alanyloxy]-2t-[N-(toluene-4-sulfonyl)-β-alanyloxymethyl]-(3ar,9ac)-2,3,3a,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-ylideneamine 
• 61341-03-5 N-(toluene-4-sulfonyl)-β-alanyl chloride 
• 62456-75-1 N-[(4-methylphenyl)sulfonyl]-β-alanine methyl ester 
• 193635-17-5 N-methoxy-N-methyl-3-((4-methylphenyl)sulfonamido)propanamide 
• 122080-99-3 3-[(4-methylphenyl)sulfonyl]-3-azabicyclo[3.2.0]heptan-6-one 
• 1626437-83-9 N-(3-(1-butyryl-2,4-dioxopyrrolidin-3-ylidene)-3-hydroxypropyl)-4-methylbenzenesulfonamide 
• 1378523-95-5 3-[prop-2-ynyl(toluene-4-sulfonyl)amino]propionic acid prop-2-ynyl ester 
• 152453-96-8 N-(2-formylethyl)-N-(3-propynyl)-p-toluenesulfonamide 

Relevant articles and documents

Ni-Catalyzed Carboxylation of Aziridines en Route to β-Amino Acids

A Ni-catalyzed reductive carboxylation of N-substituted aziridines with CO2 at atmospheric pressure is disclosed. The protocol is characterized by its mild conditions, experimental ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access β-amino acids, important building blocks with considerable potential as peptidomimetics.

Fluorescent probe for detecting peroxynitrite ions, preparation method and applications thereof

The invention provides a fluorescent probe for detecting peroxynitrite ions. The fluorescent probe provided by the invention has high specificity, is not interfered by other components in a corresponding peroxynitrite ion detection process, can be used fo

Structural and biological study of synthesized anthraquinone series of compounds with sulfonamide feature

1, 4 and 5, 8-Positions as well as type of functionalities on these positions at anthraquinone-9, 10-dione are proposed to be significant for anticancer activity. Therefore, keeping this into consideration, a series of 1-substituted anthraquinone-based compounds are designed, synthesized, characterized and biologically evaluated for anticancer activity. The structure of synthesized compounds is confirmed by spectroscopic analysis, i.e. 1D (1H and 13C) nuclear magnetic resonance (NMR), electrospray ionization-mass spectrometry (ESI-MS) studies and Fourier transform infrared (FT-IR) tools. Synthesized 1-substituted anthraquinone compounds showed cytotoxic effect against human breast cancer cell line (MCF-7), human prostate cancer cell line (PC-3) and Hela derivative human cell line (Hep 2C) (Hela derivative) cell lines. All the compounds showed mild antibacterial property in comparison to standard antibiotic streptomycin against Gram + ve and –ve bacteria. They also exhibit mild antifungal activity. In vitro calf thymus (ct)-DNA binding studies of synthesized series using UV–visible absorption spectra measurement and fluorescence tools indicate partial intercalative mode of binding. Electronic properties of synthesized analogues and mitoxantrone are compared using highest occupied molecular orbital–lowest occupied molecular orbital (HOMO–LUMO) calculation. Low energy gap between HOMO and LUMO of 1-substituted anthraquinone compounds indicates the highly charged structure of the molecules in comparison to mitoxantrone, and the same is proposed to be responsible for comparable cytotoxic activities of the synthesized 1-substituted anthraquinone molecules. Docking interaction of synthesized 1-substituted anthraquinone compounds and i-motif sequence indicates intercalative mode of binding of compounds with telomeric junction. Communicated by Ramaswamy H. Sarma.