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122081-29-2

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122081-29-2 Usage

General Description

Ethyl 2-[(4-methylbenzoyl)amino]acetate is a chemical compound with the molecular formula C13H15NO3. It is a derivative of acetate and contains a benzoyl group attached to an amino group. ETHYL 2-[(4-METHYLBENZOYL)AMINO]ACETATE is commonly used in the pharmaceutical and chemical industries as a building block for the synthesis of various organic compounds and as a reagent for chemical reactions. It has properties that make it suitable for use as a flavoring agent or fragrance in products such as perfumes, cosmetics, and food products. Additionally, it may also have potential applications in medicinal and therapeutic formulations. However, it is important to handle ethyl 2-[(4-methylbenzoyl)amino]acetate with care, as it may pose health and safety risks if mishandled or improperly used.

Check Digit Verification of cas no

The CAS Registry Mumber 122081-29-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,0,8 and 1 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 122081-29:
(8*1)+(7*2)+(6*2)+(5*0)+(4*8)+(3*1)+(2*2)+(1*9)=82
82 % 10 = 2
So 122081-29-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H15NO3/c1-3-16-11(14)8-13-12(15)10-6-4-9(2)5-7-10/h4-7H,3,8H2,1-2H3,(H,13,15)

122081-29-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 2-[(4-methylbenzoyl)amino]acetate

1.2 Other means of identification

Product number -
Other names N-p-toluoyl-glycine ethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:122081-29-2 SDS

122081-29-2Relevant articles and documents

Microwave-Assisted Ruthenium-Catalysed ortho-C?H Functionalization of N-Benzoyl α-Amino Ester Derivatives

Sharma, Nandini,Bahadur, Vijay,Sharma, Upendra K.,Saha, Debasmita,Li, Zhenghua,Kumar, Yogesh,Colaers, Jona,Singh, Brajendra K,Van der Eycken, Erik V.

supporting information, p. 3083 - 3089 (2018/08/24)

A microwave-assisted highly efficient intermolecular C?H functionalization sequence has been developed to access substituted isoquinolones using α-amino acid esters as a directing group. This methodology enables a wide range of N-benzoyl α-amino ester derivatives to react via a Ru-catalysed C?H bond activation sequence, to form isoquinolones with moderate to excellent yields. As an additional advantage, our strategy proved to be widely applicable and also enabled the reaction of alkenes to provide access to alkenylated benzamides. The methodology was also extended towards the synthesis of isoquinoline alkaloids derivatives viz. oxyavicine and a dipeptide. The developed protocol is simple and cheap, avoids tedious workup procedures and works efficiently under MW irradiation. (Figure presented.).

The α-effect in hydrazinolysis of 4-chloro-2-nitrophenyl x-substituted-benzoates: Effect of substituent x on reaction mechanism and the α-effect

Kim, Min-Young,Kim, Tae-Eun,Lee, Jieun,Um, Ik-Hwan

, p. 2271 - 2276 (2014/09/29)

Second-order rate constants (kN) have been measured spectrophotometrically for the reaction of 4-chloro-2- nitrophenyl X-substituted-benzoates (6a-6h) with a series of primary amines including hydrazine in 80 mol % H2O/20 mol % DMSO at 25.0°C. The Bronsted-type plot for the reaction of 4-chloro-2-nitrophenyl benzoate (6d) is linear with βnuc = 0.74 when hydrazine is excluded from the correlation. Such a linear Bronsted-type plot is typical for reactions reported previously to proceed through a stepwise mechanism in which expulsion of the leaving group occurs in the rate-determining step (RDS). The Hammett plots for the reactions of 6a-6h with hydrazine and glycylglycine are nonlinear. In contrast, the Yukawa-Tsuno plots exhibit excellent linear correlations with ?X = 1.29-1.45 and r = 0.53-0.56, indicating that the nonlinear Hammett plots are not due to a change in RDS but are caused by resonance stabilization of the substrates possessing an electron-donating group (EDG). Hydrazine is ca. 47-93 times more reactive than similarly basic glycylglycine toward 6a-6h (e.g., the α-effect). The α-effect increases as the substituent X in the benzoyl moiety becomes a stronger electronwithdrawing group (EWG), indicating that destabilization of the ground state (GS) of hydrazine through the repulsion between the nonbonding electron pairs on the two N atoms is not solely responsible for the substituent-dependent α-effect. Stabilization of transition state (TS) through five-membered cyclic TSs, which would increase the electrophilicity of the reaction center or the nucleofugality of the leaving group, contributes to the α-effect observed in this study.

The preparation of amides by copper-mediated oxidative coupling of aldehydes and amine hydrochloride salts

Giguère-Bisson, Maxime,Yoo, Woo-Jin,Li, Chao-Jun

, p. 14 - 21 (2014/04/03)

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