1221072-22-5Relevant articles and documents
Rational Design of Supramolecular Dynamic Protein Assemblies by Using a Micelle-Assisted Activity-Based Protein-Labeling Technology
Sandanaraj, Britto S.,Reddy, Mullapudi Mohan,Bhandari, Pavankumar Janardhan,Kumar, Sugam,Aswal, Vinod K.
, p. 16085 - 16096 (2018/10/15)
The self-assembly of proteins into higher-order superstructures is ubiquitous in biological systems. Genetic methods comprising both computational and rational design strategies are emerging as powerful methods for the design of synthetic protein complexes with high accuracy and fidelity. Although useful, most of the reported protein complexes lack a dynamic behavior, which may limit their potential applications. On the contrary, protein engineering by using chemical strategies offers excellent possibilities for the design of protein complexes with stimuli-responsive functions and adaptive behavior. However, designs based on chemical strategies are not accurate and therefore, yield polydisperse samples that are difficult to characterize. Here, we describe simple design principles for the construction of protein complexes through a supramolecular chemical strategy. A micelle-assisted activity-based protein-labeling technology has been developed to synthesize libraries of facially amphiphilic synthetic proteins, which self-assemble to form protein complexes through hydrophobic interaction. The proposed methodology is amenable for the synthesis of protein complex libraries with molecular weights and dimensions comparable to naturally occurring protein cages. The designed protein complexes display a rich structural diversity, oligomeric states, sizes, and surface charges that can be engineered through the macromolecular design. The broad utility of this method is demonstrated by the design of most sophisticated stimuli-responsive systems that can be programmed to assemble/disassemble in a reversible/irreversible fashion by using the pH or light as trigger.
Coumarin-based emissive hexacatenars: synthesis, 2D and 3D self-assembly and photodimerization
Xiao, Yulong,Tan, Xiaoping,Xing, Wei,Zhao, Kai,Zhang, Bei,Cheng, Xiaohong
, p. 10782 - 10792 (2018/10/25)
The first examples of unsymmetric coumarin polycatenar liquid crystals consisting of a coumarin central core with 1,2,3-triazole dendritic wings on both sides were synthesized via click reaction. Their properties were investigated using POM, DSC, XRD, SEM
HYDROPHOBIN MIMICS: PROCESS FOR PREPARATION THEREOF
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Paragraph 0136; 0137; 0320; 0321; 0322; 0323-0329; 0380-0389, (2017/09/02)
The present invention discloses hydrophobin mimics of formula (I) comprising a protein head group, hydrophilic linker and hydrophobic tail and to a process for synthesis of library of hydrophobin mimics thereof. The hydrophobin mimics of the present invention self-assemble to form protein nanoparticles/nanocontainer either alone or in a specified chemical environment. The hydrophobin mimics (I) of the present invention find application in area of bio-nanotechnology.
POLYCATENAR LIGANDS AND HYBRID NANOPARTICLES MADE THEREFROM
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, (2017/10/13)
Described herein are polycatenar ligand compounds and their use in the production of hybrid nanoparticles, typically nanocrystals. The present disclosure also relates to films containing the hybrid nanoparticles described herein and their use.
Polycatenar Ligand Control of the Synthesis and Self-Assembly of Colloidal Nanocrystals
Diroll, Benjamin T.,Jishkariani, Davit,Cargnello, Matteo,Murray, Christopher B.,Donnio, Bertrand
, p. 10508 - 10515 (2016/09/04)
Hydrophobic colloidal nanocrystals are typically synthesized and manipulated with commercially available ligands, and surface functionalization is therefore typically limited to a small number of molecules. Here, we report the use of polycatenar ligands d
PRODUCTION METHOD OF OLIGONUCLEOTIDE
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, (2012/12/13)
The problem of the present invention is provision of a method of producing an n+p-mer oligonucleotide efficiently in a high yield, which includes use of, as a starting material, an n-mer oligonucleotide wherein the 3′-terminal hydroxyl group is protected,
Design, synthesis, and self-assembly behavior of C3-symmetry discotic molecules via click chemistry
Ryu, Mi-Hee,Choi, Jin-Woo,Cho, Byoung-Ki
experimental part, p. 1806 - 1810 (2010/07/08)
We prepared a series of C3-symmetry discogens with three 1,2,3-triazoles and a central benzene ring by a copper-catalyzed "click reaction" between 1,3,5-triethynylbenzene and 3,4,5-trialkoxybenzyl azides. According to the differential scanning