1221133-67-0

Basic information

• Product Name: 4-(2,4-dichlorophenyl)-3-phenyl-1H-pyrazol-5-amine
• CAS NO: 1221133-67-0
• Molecular Weight: 304.178
• Mol File: 1221133-67-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2,4-dichlorophenyl)-3-phenyl-1H-pyrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,4-dichlorophenyl)-3-phenyl-1H-pyrazol-5-amine(1221133-67-0)
• EPA Substance Registry System: 4-(2,4-dichlorophenyl)-3-phenyl-1H-pyrazol-5-amine(1221133-67-0)

Safety Data

• Hazardous Substances Data: 1221133-67-0(Hazardous Substances Data)

Upstream product

• 6306-60-1 2,4-Dichlorophenylacetonitrile 
• 93-89-0 benzoic acid ethyl ester 

Downstream Products

• 1221129-50-5 3-(2,4-dichlorophenyl)-2-phenyl-5-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 

Relevant articles and documents

Synthesis, crystal structure and antitumor activity of 3-(2,4-dichlorophenyl)-2-phenyl-5-(p-tolyl)-7-(trifluoromethyl)pyrazolo[1,5-A]pyrimidine

The title compound, 3-(2,4-dichlorophenyl)-2-phenyl-5-(p-tolyl)- 7-(trifluoromethyl)pyrazolo[1,5-a] pyrimidine (C26H16C12F3N3, Mr = 498.32) has been synthesized by condensation of 4,4,4-trifluoro-1-(p-tolyl)butane- 1,3-dione with 4-(2,4-dichlorophenyl)-3-phenyl-1H-pyrazol-5-amine. The latter was prepared from 2,4-dichlorophenylaceton itrile and ethyl benzoate through Claisen condensation and then cyclization with hydrazine hydrate. The crystal structure of the title compound was determined. In addition, the title compound possesses marked inhibition against the proliferation of human lung adenocarcinoma cell line A549 and human gastric cancer cell line MKN45, displaying promising anticancer activities.