1221157-10-3

Basic information

• Product Name: 4-[(2,4-dinitrophenyl)methylcarbamoyl]butyric acid methyl ester
• Synonyms: 4-[(2,4-dinitrophenyl)methylcarbamoyl]butyric acid methyl ester
• CAS NO: 1221157-10-3
• Molecular Weight: 325.278
• Mol File: 1221157-10-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-[(2,4-dinitrophenyl)methylcarbamoyl]butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2,4-dinitrophenyl)methylcarbamoyl]butyric acid methyl ester(1221157-10-3)
• EPA Substance Registry System: 4-[(2,4-dinitrophenyl)methylcarbamoyl]butyric acid methyl ester(1221157-10-3)

Safety Data

• Hazardous Substances Data: 1221157-10-3(Hazardous Substances Data)

Upstream product

• 97-02-9 2,4-Dinitroanilin 
• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 
• 2044-88-4 N-methyl-2,4-dinitroaniline 
• 1221157-09-0 4-(2,4-dinitrophenylcarbamoyl)butyric acid methyl ester 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 

Downstream Products

• 109882-25-9 4-{5-[bis-(2-chloro-ethyl)amino]-1-methyl-1H-benzoimidazol-2-yl}butyric acid methyl ester 
• 3543-75-7 bendamustine hydrochloride 

Relevant articles and documents

Improved continuous flow processing: Benzimidazole ring formation via catalytic hydrogenation of an aromatic nitro compound

In the development of a new route to bendamustine hydrochloride, the API in Treanda, the key benzimidazole intermediate 5 was generated via catalytic heterogeneous hydrogenation of an aromatic nitro compound using a batch reactor. Because of safety concer

PROCESSES FOR THE PREPARATION OF BENDAMUSTINE

New methods for the preparation of bendamustine, and the pharmaceutical salts thereof, are described. Novel compounds useful for the preparation of bendamustine are also described.