109882-25-9Relevant articles and documents
Improved continuous flow processing: Benzimidazole ring formation via catalytic hydrogenation of an aromatic nitro compound
Chen, Jian,Przyuski, Katrin,Roemmele, Renee,Bakale, Roger P.
, p. 1427 - 1433 (2014)
In the development of a new route to bendamustine hydrochloride, the API in Treanda, the key benzimidazole intermediate 5 was generated via catalytic heterogeneous hydrogenation of an aromatic nitro compound using a batch reactor. Because of safety concer
Process for the preparation of bendamustine hydrochloride and related compounds
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Paragraph 0146; 0147; 0148; 0149; 0150, (2013/07/25)
The present invention relates to a process for preparing bendamustine hydrochloride, derivatives and related compounds thereof.
PROCESSES FOR THE PREPARATION OF BENDAMUSTINE
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Page/Page column 19-20, (2010/04/28)
New methods for the preparation of bendamustine, and the pharmaceutical salts thereof, are described. Novel compounds useful for the preparation of bendamustine are also described.