122127-80-4Relevant academic research and scientific papers
Selective lewis acid catalyzed assembly of phosphonomethyl ethers: Three-step synthesis of tenofovir
Ocampo, Charles E.,Lee, Doris,Jamison, Timothy F.
, p. 820 - 823 (2015)
Described herein is a novel Lewis acid catalyzed rearrangement-coupling of oxygen heterocycles and bis(diethylamino)chlorophosphine that provides direct formation of the phosphonomethyl ether functionality found in several important antiretroviral agents. A wide range of dioxolanes and 1,3-dioxanes may be employed, furnishing the desired products in good yield. The utility of this method is demonstrated in a novel synthesis of tenofovir, an antiretroviral drug used in the treatment of HIV/AIDS and hepatitis B.
