19210-21-0

Basic information

• Product Name: (S)-(+)-2-Chloropropan-1-ol
• Synonyms: (S)-(-)-2-CHLORO-1-PROPANOL;(S)-(+)-2-CHLORO-1-PROPANOL;(S)-2-CHLORO-1-PROPANOL;(S)-(+)-2-CHLOROPROPAN-1-OL;(S)-(+)-PROPYLENE CHLOROHYDRIN;(s)-1-propano;1-PROPANOL, 2-CHLORO-, (2S)-;(S)-(+)-2- Chloro-2-propanol
• CAS NO: 19210-21-0
• Molecular Formula: C₃H₇ClO
• Molecular Weight: 94.54
• EINECS: 201-153-8
• Product Categories: Organics;chiral;Alcohols;Chiral Building Blocks;Organic Building Blocks
• Mol File: 19210-21-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 70.3 °C75 mm Hg(lit.)
• Flash Point: 112 °F
• Appearance: clear colourless to slightly yellow liquid
• Density: 1.103 g/mL at 25 °C(lit.)
• Vapor Pressure: 3.68mmHg at 25°C
• Refractive Index: n20/D 1.438(lit.)
• Storage Temp.: Flammables area
• PKA: 14.16±0.10(Predicted)
• Water Solubility: soluble
• CAS DataBase Reference: (S)-(+)-2-Chloropropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-2-Chloropropan-1-ol(19210-21-0)
• EPA Substance Registry System: (S)-(+)-2-Chloropropan-1-ol(19210-21-0)

Safety Data

• Hazard Codes: Xn
• Statements: 10-20/21/22-36-36/37/38
• Safety Statements: 16-26-27-36/37/39-45
• RIDADR: UN 2611 6.1/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 19210-21-0(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS TO SLIGHTLY YELLOW LIQUID

Uses

Chloro-1-propanol can be used to treat cardiovascular diseases.

InChI:InChI=1/C3H7ClO/c1-3(4)2-5/h3,5H,2H2,1H3/t3-/m0/s1

Upstream product

• 187737-37-7 propene 
• 104897-94-1 (S)-2-Chloro-propionic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 

Downstream Products

• 74282-28-3 (S)-1,2-dichloropropane 
• 1072-47-5 (R)-4-methyl-1,3-dioxolane 
• 15448-47-2 (R)-propylene oxide 
• 1353657-21-2 4-[(1R)-2-hydroxy-1-methylethoxy]benzaldehyde 
• 16088-62-3 (S)-Propylene oxide 

Relevant articles and documents

Oxidation of olefins by palladium(II): Part 17. An asymmetric chlorohydrin synthesis catalyzed by a bimetallic palladium(II) complex

Previous studies showed that oxidation of α-olefins with monometallic catalysts containing chiral diphosphines and diamines gave chlorohydrins with poor to good enantioselectivites (28-82% ee). The present studies demonstrate that bimetallic catalysts containing a β-triketone and bridging chiral diphosphine and diamines are excellent catalysts for this reaction giving enantioselectivites considerably higher than the monometallic catalysts. Enantioselectivities were more than 50% for most olefins tested. The highest optical purities were 94% ee for propene and 93% ee for allylphenyl ether. A useful feature of this asymmetric synthesis is the fact it is a net air oxidation.