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ethyl 4-(1-(benzyloxy)-5-(biphenyl-3-yl)-1H-pyrazol-4-yl)piperidine-1-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1221275-01-9

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1221275-01-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1221275-01-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,1,2,7 and 5 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1221275-01:
(9*1)+(8*2)+(7*2)+(6*1)+(5*2)+(4*7)+(3*5)+(2*0)+(1*1)=99
99 % 10 = 9
So 1221275-01-9 is a valid CAS Registry Number.

1221275-01-9Relevant academic research and scientific papers

Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as γ-aminobutyric acidA receptor ligands: Synthesis, pharmacology, and structure-activity relationships

Fr?lund, Bente,M?ller, Henriette A.,Sander, Tommy,Kristensen, Jesper L.,Nielsen, Birgitte,Krall, Jacob,Bergmann, Marianne L.,Christiansen, Bolette,Balle, Thomas,Jensen, Anders A.

supporting information; experimental part, p. 3417 - 3421 (2010/09/05)

A series of substituted 1-hydroxypyrazole analogues of the GABAA receptor partial agonist 5-(4-piperidyl)-3-isoxazolol (4-PIOL) have been synthesized and pharmacologically characterized. Several of the analogues displayed Ki in the low nanomolar range at the native GABA A receptors and potent antagonism of the α1β 2γ2 receptor. It appears that several regions situated in proximity to the core of the orthosteric binding site of the GABAA receptor are able to accommodate large hydrophobic substituents.

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