1221430-61-0Relevant articles and documents
Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists
Shook, Brian C.,Chakravarty, Devraj,Barbay, J. Kent,Wang, Aihua,Leonard, Kristi,Alford, Vernon,Powell, Mark T.,Rassnick, Stefanie,Scannevin, Robert H.,Carroll, Karen,Wallace, Nathaniel,Crooke, Jeffrey,Ault, Mark,Lampron, Lisa,Westover, Lori,Rhodes, Kenneth,Jackson, Paul F.
, p. 2688 - 2691 (2013/06/27)
A novel series of benzyl substituted thieno[2,3-d]pyrimidines were identified as potent A2A receptor antagonists. Several five- and six-membered heterocyclic replacements for the optimized methylfuran were explored. Select compounds effectively reverse catalepsy in mice when dosed orally.
