1221443-39-5

Basic information

• Product Name: 5-((R)-α-methylbenzyl)-7-hydroxy-5-azaspiro[2.4]heptane
• Synonyms: 5-((R)-α-methylbenzyl)-7-hydroxy-5-azaspiro[2.4]heptane
• CAS NO: 1221443-39-5
• Molecular Weight: 217.311
• Mol File: 1221443-39-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-((R)-α-methylbenzyl)-7-hydroxy-5-azaspiro[2.4]heptane(CAS DataBase Reference)
• NIST Chemistry Reference: 5-((R)-α-methylbenzyl)-7-hydroxy-5-azaspiro[2.4]heptane(1221443-39-5)
• EPA Substance Registry System: 5-((R)-α-methylbenzyl)-7-hydroxy-5-azaspiro[2.4]heptane(1221443-39-5)

Safety Data

• Hazardous Substances Data: 1221443-39-5(Hazardous Substances Data)

Upstream product

• 129306-05-4 ethyl 1-(2-bromoacetyl)cyclopropanecarboxylate 
• 32933-03-2 ethyl 1-acetylcyclopropanecarboxylate 
• 127199-37-5 4,7-dioxo-5-<1(R)-phenylethyl>-5-azaspiro<2.4>heptane 

Downstream Products

• 944258-72-4 7-hydroxy-5-azaspiro[2.4]heptane 
• 1221443-13-5 N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1221442-95-0 N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide 
• 1221443-01-1 N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-phenylcyclopropane-1,1-dicarboxamide 
• 1221442-96-1 N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)quinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide 
• 1221442-98-3 N-(5-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)pyridin-2-yl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide 
• 1221442-99-4 N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)quinolin-4-yloxy)-3-fluorophenyl)-N-phenylcyclopropane-1,1-dicarboxamide 
• 1221443-14-6 N'-(5-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)pyridin-2-yl)-N-phenylcyclopropane-1,1-dicarboxamide 
• 1221442-97-2 N-(5-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)quinolin-4-yloxy)pyridin-2-yl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide 
• 1221443-00-0 N'-(5-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)quinolin-4-yloxy)pyridin-2-yl)-N-phenylcyclopropane-1,1-dicarboxamide 

Relevant articles and documents

AMINO ESTER DERIVATIVES, SALTS THEREOF AND METHODS OF USE

The present invention provides amino ester compounds, salts, and pharmaceutical formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

COMPOUNDS AND METHODS OF USE

The present invention provides novel compounds useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.