122148-97-4Relevant academic research and scientific papers
Design, Synthesis and Evaluation of AdSS Bisubstrate Inhibitors
Tibrewal, Nidhi,Elliott, Gregory I.
, p. 2269 - 2272 (2020)
Many cancers lack the expression of methylthioadenosine phosphorylase (MTAP). These cancers require adenylosuccinate synthetase (AdSS) for nucleic acid synthesis. By inhibiting adenylosuccinate synthetase, we potentially have a new therapeutic agent. Bisubstrate inhibitors were synthesized and evaluated against purified AdSS. The best activity was obtained with adenosine bearing a four-carbon linker that connects the N-formyl-N-hydroxy moiety to the 6-position of the purine nucleoside.
FUSED TRI-CYCLIC COMPOUND AS PDE3/PDE4 DUAL INHIBITOR
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Paragraph 0144-0145, (2021/05/20)
Provided is a fused tri-cyclic compound as PDE3/PDE4 dual inhibitor, and a use thereof in the preparation of drugs for PDE3/PDE4 associated diseases, particularly in medicinal functions such as chronic obstructive pulmonary disease (COPD). Provided are sp
ALKYLATION OF N-BENZYLOXYUREAS AND CARBAMATES
Sulsky, Richard,Demers, James P.
, p. 31 - 34 (2007/10/02)
N-benzyloxyureas and orthogonically protected N-hydroxycarbamates can be alkylated in high yields and subsequently deprotected to provide N-alkyl hydroxyureas and hydroxylamines.
