1221593-62-9

Basic information

• Product Name: {2-[H-Arg(Pbf)]-aminoethyl}-ethyl-carbamic acid benzyl ester
• Synonyms: {2-[H-Arg(Pbf)]-aminoethyl}-ethyl-carbamic acid benzyl ester
• CAS NO: 1221593-62-9
• Molecular Weight: 630.809
• Mol File: 1221593-62-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: {2-[H-Arg(Pbf)]-aminoethyl}-ethyl-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {2-[H-Arg(Pbf)]-aminoethyl}-ethyl-carbamic acid benzyl ester(1221593-62-9)
• EPA Substance Registry System: {2-[H-Arg(Pbf)]-aminoethyl}-ethyl-carbamic acid benzyl ester(1221593-62-9)

Safety Data

• Hazardous Substances Data: 1221593-62-9(Hazardous Substances Data)

Upstream product

• 186698-61-3 (S)-2-(tert-butoxycarbonylamino)-5-(3-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)guanidino)pentanoic acid 
• 1221593-61-8 {2-[boc-Arg(Pbf)]-aminoethyl}-ethyl-carbamic acid benzyl ester 
• 200124-22-7 Boc-Arg-(Pbf)-OH 
• 1221593-60-7 (2-amino-ethyl)-ethyl-carbamic acid benzyl ester hydrochloride 
• 1221593-59-4 ethyl-[2-(2,2,2-trifluoro-acetylamino)-ethyl]carbamic acid benzyl ester 
• 126955-78-0 (2-amino-ethyl)-ethyl-carbamic acid benzyl ester 

Downstream Products

• 1221593-63-0 {2-[Ac-Arg(Pbf)]-aminoethyl}-ethyl-carbamic acid benzyl ester 

Relevant articles and documents

COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OPIOID PRODRUGS AND INHIBITORS THEREOF

The present disclosure provides pharmaceutical compositions, and their methods of use, where the pharmaceutical compositions comprise a prodrug that provides enzymatically-controlled release of a drug and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the drug from the prodrug so as to attenuate enzymatic cleavage of the prodrug. The disclosure provides pharmaceutical compositions which comprise an enzyme inhibitor and a prodrug that contains an enzyme-cleavable moiety that, when cleaved, facilitates release of the drug.

COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OPIOID PRODRUGS AND INHIBITORS THEREOF

Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise an opioid prodrug that provides enzymatically-controlled release of an opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the opioid from the opioid prodrug so as to attenuate enzymatic cleavage of the opioid prodrug.