186698-61-3

Basic information

• Product Name: BOC-D-ARG(PBF)-OH
• Synonyms: N-ALPHA-(T-BUTYLOXYCARBONYL)-N'-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-D-ARGININE;N-ALPHA-(TERT-BUTYLOXYCARBONYL)-N'-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-D-ARGININE;BOC-D-ARGININE(PBF)-OH;BOC-D-ARG(PBF)-OH;BOC-N-OMEGA-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-D-ARGININE;BOC-D-Arg(pbf);Boc-N-oMega-(2,2,4,6,7-pentaMethyldihydrobenzofuran-5-sufonyl)-D-arginine;N^a-Boc-N^w-(2,2,4,6,7-pentaMethyl-2,3-dihydrobenzo[b]furan-5-ylsulfonyl)-D-arginine, 95%
• CAS NO: 186698-61-3
• Molecular Formula: C24H38N4O7S
• Molecular Weight: 526.65
• Mol File: 186698-61-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /Solid
• Density: 1.31±0.1 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 3.94±0.21(Predicted)
• CAS DataBase Reference: BOC-D-ARG(PBF)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-ARG(PBF)-OH(186698-61-3)
• EPA Substance Registry System: BOC-D-ARG(PBF)-OH(186698-61-3)

Safety Data

• Hazardous Substances Data: 186698-61-3(Hazardous Substances Data)

Usage

General Description

BOC-D-ARG(PBF)-OH is a chemical compound often used in the synthesis of peptides. It consists of a protected form of the amino acid arginine, with a BOC (tert-butyloxycarbonyl) group blocking the amine group and a PBF (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl) group blocking the guanidino group. BOC-D-ARG(PBF)-OH is commonly used in solid-phase peptide synthesis to build peptide chains, as the BOC and PBF groups can be removed or modified in subsequent steps to allow for the addition of additional amino acids. BOC-D-ARG(PBF)-OH is a key component in the production of complex peptides, which are used in a variety of biological and pharmaceutical applications.

Upstream product

• 35897-34-8 N^α-t-butoxycarbonyl-arginine hydrochloride 
• 154445-78-0 2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl chloride 

Downstream Products

• 1538609-34-5 C₄₁H₅₀F₃N₇O₈S₂ 
• 1273327-72-2 H₂N-Arg(Pbf)-Gly-OBn 

Relevant articles and documents

Triazole groups as biomimetic amide groups in peptides can trigger racemization

Amino acids are key building blocks for the synthesis of chiral organic materials. In this context, α-azido amino acids are interesting starting materials which allow the construction of functionalized, amino-acid based compounds by copper-catalyzed alkyn