122164-23-2

Upstream product

• 94-41-7 benzalacetophenone 
• 827-41-8 3-phenylpyrazol-5-amine 
• 120-46-7 1,3-diphenylpropanedione 
• 614-16-4 Benzoylacetonitrile 
• 87119-67-3 5,7-Dimethyl-2-phenylpyrazolo<1,5-a>pyrimidine 
• 6263-84-9 1,3,5-triphenyl-1,5-pentanedione 
• 1572-10-7 3⁽⁵⁾-phenylpyrazol-5⁽³⁾-amine 
• 611-91-6 2,3-dibromo-1,3-diphenylpropane-1-one 
• 122164-14-1 2,5,7-triphenyl-6,7-dihydropyrazolo<1,5-a>pyrimidine 

Downstream Products

• 802983-96-6 3-iodo-2,5,7-triphenyl-pyrazolo[1,5-a]pyrimidine 

Relevant academic research and scientific papers

Synthesis of N-alkylated derivatives of pyrazolo[1,5-a]-pyrimidine and their reaction with methylamine

With the object of studying the factors influencing the course of enamine rearrangements, we have carried out the N-alkylation of alkyl- and aryl-substituted pyrazolo[1,5-a]pyrimidines. Using the NOEDIF NMR spectroscopic method for the cases of 5,7-dimeth

Carbon-Carbon Bond Cleavage Reaction: Synthesis of Multisubstituted Pyrazolo[1,5-a]pyrimidines

A new carbon-carbon bond cleavage reaction was developed for the efficient synthesis of multisubstituted pyrazolo[1,5-a]pyrimidines. This base induced reaction of 1,3,5-trisubstituted pentane-1,5-diones and substituted pyrazoles afforded good yields of the pyrazolo[1,5-a]pyrimidines.

Synthesis of 5,7-diarylpyrazolo[1,5-a]pyrimidines via KOH mediated tandem reaction of 1H-pyrazol-3-amines and chalcones

An efficient and facile protocol has been developed for the synthesis of pyrazolo[1,5-a]pyrimidines through the tandem reaction of 3-aminopyrazoles and chalcones in the presence of catalytic amounts of KOH. The reported method offers access to 5,7-diarylp

Convenient synthesis of substituted 3-alkenylpyrazolo[1,5-a]pyrimidines via Heck cross-coupling reaction

3-Iodopyrazolo[1,5-a]pyrimidines 3 were easily obtained by direct iodination of pyrazolo[1,5-a]pyrimidines 2 with NIS and could be transformed into a series of new substituted 3-alkenyl-pyrazolo[1,5-a]pyrimidines 5 by Heck cross-coupling.

Pyrazolopyrimidines based on 5-aminopyrazoles unsubstituted at the position 1

By condensation of various symmetric β-diketones with a series of 5-aminopyrazoles that are unsubstituted at the position 1, we have obtained a series of pyrazolo[1,5-a]pyrimidines that are of interest as physiologically active compounds. Hexafluoroacetylacetone reacts in another direction, forming pyrazolo[4,5-b]pyridine.

α-Aminoazoles in the synthesis of heterocycles: I. Synthesis of regioisomeric 5-methyl-2,7-diphenyl-and 7-methyl-2,5-diphenylpyrazolo[1,5-a]pyrimidines

4-Phenyl-3-butyn-2-one reacts with 3(5)-amino-5(3)-phenylpyrazole on heating in DMSO to give 7-methyl-2,5-diphenylpyrazolo[1,5-a]pyrimidine. The reaction of 3(5)-amino-5(3)-phenylpyrazole with benzoylacetone in chloroform, ethanol, and DMSO results in formation of a mixture of isomeric pyrazolopyrimidines, the major product being 5-methyl-2,7-diphenylpyrazolo[1,5-a]pyrimidine.

Aryl-Substituted 6,7-dihydropyrazolopyrimidine

We have studied the reaction of 5-amino-3-phenylpyrazole with chalcones which takes place with the formation of arylsubstituted forms of dihydropyrazolopyrimidine and have discussed a possible mechanism for the reaction.Dehydrogenation of the compounds prepared has been effected using N-bromosuccinimide.