122172-30-9

Upstream product

• 122172-29-6 (R)-3-(4-methoxyphenyl)-3-<2-(1,3-dithiolanyl)>-5-<2-(2-methyl-1,3-dithiolanyl)>pentan-1-al 
• 122172-24-1 (2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2R)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate 
• 122172-25-2 (S)-2-[1,3]Dithiolan-2-yl-2-(4-methoxy-phenyl)-4-(2-methyl-[1,3]dithiolan-2-yl)-butyric acid (1S,2R,3R,4S)-4,7,7-trimethyl-3-naphthalen-1-yl-bicyclo[2.2.1]hept-2-yl ester 
• 122172-28-5 2-[(E)-(R)-3-[1,3]Dithiolan-2-yl-5-methoxy-3-(4-methoxy-phenyl)-pent-4-enyl]-2-methyl-[1,3]dithiolane 
• 122172-26-3 (S)-2-(4-methoxyphenyl)-2-<2-(1,3-dithiolanyl)>-4-<2-(2-methyl-1,3-dithiolanyl)>butan-1-ol 
• 122172-27-4 (S)-2-(4-methoxyphenyl)-2-<2-(1,3-dithiolanyl)>-4-<2-(2-methyl-1,3-dithiolanyl)>butanal 

Downstream Products

• 122172-32-1 (S)-4-(4-methoxyphenyl)-4-<2-(phenylmethoxy)eth-1-yl>cyclohex-2-en-1-one 
• 122211-69-2 (+)-O-methyljoubertiamine 
• 122172-31-0 (R)-1-(phenylmethoxy)-3-(4-methoxyphenyl)-3-<2-(1,3-dithiolanyl)>-5-<2-(2-methyl-1,3-dithiolanyl)>pentane 

Relevant academic research and scientific papers

Enantioselective Robinson Annulation: Synthesis of (+)-O-Methyljoubertiamine

The α-formyl ester derived from 2-(1-naphthyl)-3-borneol, as the potassium salt in moist dimethoxymethane, adds to methyl vinyl ketone to give two adducts in a ratio of 95:5.The relative configuration of the major diastereomer has been confirmed by X-ray crystallography.This diastereomer is readily carried on to (+)-O-methyljoubertiamine.The addition of such naphthylbornyl esters to Michael acceptors should constitute a general laboratory-scale procedure for the enantioselective construction of enantiomerically pure quaternary stereogenic centers.