1221726-75-5

Basic information

• Product Name: (S)-3-(diethylphosphoryl)-3-phenyl-1-pyrrol-1-yl-propan-1-one
• Synonyms: (S)-3-(diethylphosphoryl)-3-phenyl-1-pyrrol-1-yl-propan-1-one
• CAS NO: 1221726-75-5
• Molecular Weight: 303.341
• Mol File: 1221726-75-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-3-(diethylphosphoryl)-3-phenyl-1-pyrrol-1-yl-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(diethylphosphoryl)-3-phenyl-1-pyrrol-1-yl-propan-1-one(1221726-75-5)
• EPA Substance Registry System: (S)-3-(diethylphosphoryl)-3-phenyl-1-pyrrol-1-yl-propan-1-one(1221726-75-5)

Safety Data

• Hazardous Substances Data: 1221726-75-5(Hazardous Substances Data)

Upstream product

• 7215-33-0 diethylphosphine oxide 
• 949013-80-3 3-phenyl-1-pyrrol-1-yl-2-propen-1-one 

Relevant articles and documents

Catalytic asymmetric hydrophosphinylation of α,β-unsaturated N -acylpyrroles: Application of dialkyl phosphine oxides in enantioselective synthesis of chiral phosphine oxides or phosphines

Dialkyl phosphine oxides were introduced in catalytic asymmetric transformations for the first time. An unprecedented phospha-Michael reaction of dialkyl phosphine oxide with α,β-unsaturated N-acylpyrroles was disclosed. Excellent enantioselectivities (94→99% ee) and chemical yields (up to 99%) were achieved with a broad substrate scope of the N-acylpyrroles. Importantly, pyridine was found to be critical to achieve good results for the present reaction.