122184-76-3

Upstream product

• 73090-40-1 3-chloro-1-(phenylselanyl)propane 
• 1666-13-3 diphenyl diselenide 
• 627-31-6 1,3-Diiodopropane 

Downstream Products

• 153597-87-6 diethyl (3-benzeneselenylpropyl)(2-propen-1-yl)propanedioate 
• 191542-43-5 1-<3-(phenylselanyl)propyl>-2-(phenylsulfanyl)-1H-benzimidazole 
• 457925-19-8 4-phenyl-1-[3-(phenylselanyl)propyl]-1H-pyrazole 
• 941306-84-9 5,6-dimethyl-1-[3-(phenylseleno)propyl]-1H-benzimidazole 
• 895582-01-1 4-({1-[(3-phenylselanyl)propyl]-1H-benzo[d]imidazol-2-yl}sulfanyl)benzoic acid 
• 137265-72-6 3-Bromo-2-(3'-phenylselenopropyl)-cyclohex-2-enone 
• 137265-71-5 3-(3'-Phenylselenopropyl)-cyclohexane-1,3-dione 
• 182635-04-7 2-(3-Phenylselanyl-propyl)-pent-4-enoic acid ethyl ester 
• 171190-54-8 5-benzeneselenyl-2-(2-propen-1-yl)pentanal 
• 191542-46-8 1-<3-(phenylselanyl)propyl>-2-(phenylsulfonyl)-1H-imidazole 
• 191542-47-9 1-<3-(phenylselanyl)propyl>-2-(phenylsulfanyl)-1H-imidazole 
• 199192-30-8 2-(diethoxymethyl)-1-<3-(phenylselanyl)propyl>-1H-imidazole 
• 191542-40-2 1-<3-(phenylselanyl)propyl>-2-tosyl-1H-imidazole 
• 137265-70-4 2,4-Dimethoxy-3-(3'-phenylselenopropyl)-cyclohexa-1,4-diene 

Relevant academic research and scientific papers

Radical cyclisation onto imidazoles and benzimidazoles

New synthetic methodology has been developed for the synthesis of [1,2- a]fused imidazoles and benzimidazoles using intramolecular homolytic aromatic substitution. In the intramolecular substitution, N-(ω-alkyl) radicals are generated using Bu3SnH from N-(ω-phenylselanyl)alkyl side chains. Phenylselanyl groups are used as radical leaving groups to avoid problems in the N-alkylation of imidazoles and benzimidazoles. Arylsulfones for imidazoles, and phenylsulfides for benzimidazoles, are used at the leaving groups in the homolytic substitutions.

CARBOCYCLIC RING EXPANSION REACTIONS VIA RADICAL CHAIN PROCESSES

A free radical mediated ring expansion of cis- and trans-α-alkylated-β-stannylcyclohexanones to provide efficient routes to cis- and trans-cyclononenones and cyclodecenones is described.The cis-/trans- relationship in the precursor was found to have signi