1221963-57-0Relevant academic research and scientific papers
3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: Structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds
Stroba, Adriana,Schaeffer, Francis,Hindie, Valerie,Lopez-Garcia, Laura,Adrian, Iris,Fr?hner, Wolfgang,Hartmann, Rolf W.,Biondi, Ricardo M.,Engel, Matthias
, p. 4683 - 4693 (2009)
The modulation of protein kinase activities by low molecular weight compounds is a major goal of current pharmaceutical developments. In this line, important efforts are directed to the development of drugs targeting the conserved ATP binding site. Howeve
