1222-05-5

Basic information

• Product Name: GALAXOLIDE
• Synonyms: ABBALIDE;1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYLCYCLOPENTA[G]-2-BENZOPYRAN;1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYL-CYCLOPENTA-GAMMA-2-BENZOPYRAN;GALAXOLIDE;GALAXOLIDE 50;GALAXOLIDE 50 BB;GALAXOLIDE 50 IPM;HHCB
• CAS NO: 1222-05-5
• Molecular Formula: C₁₈H₂₆O
• Molecular Weight: 258.4
• EINECS: 214-946-9
• Product Categories: Alphabetical Listings;Flavors and Fragrances;G-H;Aromatics;Detergents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1222-05-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 57-58°
• Boiling Point: 304 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.044 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000414mmHg at 25°C
• Refractive Index: n20/D 1.5215(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: 不溶于水，溶于乙醇和油。
• CAS DataBase Reference: GALAXOLIDE(CAS DataBase Reference)
• NIST Chemistry Reference: GALAXOLIDE(1222-05-5)
• EPA Substance Registry System: GALAXOLIDE(1222-05-5)

Safety Data

• Hazard Codes: Xi,N
• Statements: 38-50/53
• Safety Statements: 26-36-61
• RIDADR: UN 3082 9 / PGIII
• WGK Germany: 3
• HazardClass: 9
• PackingGroup: III
• Hazardous Substances Data: 1222-05-5(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 1222-05-5 differently. You can refer to the following data:
1. Clear Colourless to Pale Yellow Oil
2. 4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]benzopyran is a viscous liquid with a musk-like odor. It is one of the most frequently used synthetic, artificial musk fragrances.The starting material for its synthesis is 1,1,2,3,3-pentamethylindane, which is prepared by cycloaddition of tert-amylene to α-methylstyrene. The pentamethylindane is hydroxyalkylated with propylene oxide in a Friedel–Crafts reaction using aluminum chloride as a catalyst (analogous to the synthesis of phenylethyl alcohol from benzene and ethylene oxide . Ring closure of the resulting 1,1,2,3,3-pentamethyl-5-(β-hydroxyisopropyl)indane is accomplished with paraformaldehyde and a lower aliphatic alcohol via the acetal or with paraformaldehyde and a carboxylic acid anhydride via the acylate.The commercial product is diluted with solvents (e.g., diethyl phthalate, isopropyl myristate, benzyl benzoate) to make it less viscous. It is alkali-stable and does not discolor in light. Therefore, it is a popular ingredient of perfume compositions for soaps, detergents, and cosmetics and is used in large amounts.

Uses

Galaxolide is a polycyclic musk (PCM) used as a fragrance ingredient in perfumes, soaps, cosmetics and detergents.

Definition

ChEBI: An organic heterotricyclic compound that is 1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene substituted by methyl groups at positions 4, 6, 6, 7, 8 and 8 respectively. It is a synthetic musk used as a fragrance in cosmetics.

General Description

1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran is an isochromone with a strong musk odor, commonly used in fragrances.

Flammability and Explosibility

Notclassified

Trade name

Galaxolide? (IFF), Astromusk (Agan),Musk YingHai (YingHai).

InChI:InChI=1/C18H26O/c1-11-9-19-10-13-7-15-16(8-14(11)13)18(5,6)12(2)17(15,3)4/h7-8,11-12H,9-10H2,1-6H3

Upstream product

• 1195-32-0 1-methyl-4-isopropenylbenzene 
• 1203-17-4 1,1,2,3,3-pentamethylindane 
• 1217-08-9 2-(1',1',2',3',3'-pentamethyl-5'-indanyl)-1-propanol 
• 4834-28-0 1,1,2,3,3,6-hexamethyl-1H-indane 
• 75-56-9 methyloxirane 
• 109-87-5 Dimethoxymethane 
• 50-00-0 formaldehyd 
• 110-88-3 1,3,5-Trioxan 
• 628-51-3 diacetoxymethane 
• 594-60-5 2,3-dimethylbutan-2-ol 
• 563-79-1 2,3-Dimethyl-2-butene 
• 75-36-5 acetyl chloride 
• 2084-69-7 1,1,2,4,4,7-hexamethyl-1,2,3,4-tetrahydro-naphthalene 

Downstream Products

• 507442-49-1 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[γ]-2-benzopyran-1-one 

Related news

Avoidance behaviour of the shrimp Palaemon varians regarding a contaminant gradient of GALAXOLIDE (cas 1222-05-5) and tonalide in seawater07/28/2019

The musk fragrances galaxolide (HHCB) and tonalide (AHTN) are compounds of emerging concern that have been found in various environmental compartments. The present study addressed the ability of HHCB and AHTN to elicit the avoidance response in the estuarine shrimp Palaemon varians and to predic...detailed

Ball-milled biochar for GALAXOLIDE (cas 1222-05-5) removal: Sorption performance and governing mechanisms07/27/2019

The environmental risk of galaxolide (HHCB) spurs the need to develop efficient and economical removal technology. Although sorption is one of the best removal approaches, studies on sorption of HHCB by biochar were limited. With the purpose of combining the advantages of ball-milling and sorpti...detailed

Preliminary assessment of GALAXOLIDE (cas 1222-05-5) bioaccessibility in raw and cooked FISH07/26/2019

Generally, dietary intake assessment and risk characterization are evaluated using contaminant concentration in raw fish while it is usually ingested cooked, which can cause an overestimation because one of the essential issues for risk-benefit analysis is to determine the maximum amount of a co...detailed

Vaporization enthalpy and vapor pressure of (−) Ambroxide and GALAXOLIDE (cas 1222-05-5) by correlation gas chromatography07/25/2019

The vapor pressures and vaporization enthalpies of dibenzofuran, (−) Ambroxide™ and Galaxolide™ are evaluated by correlation gas chromatography. (−) Ambroxide™ and Galaxolide™ are important commercial products, the latter of which has been the subject of some controversy regarding its impact on ...detailed

Relevant articles and documents

Preparation method of galaxolide

The invention discloses a preparation method of galaxolide, which comprises the following steps: under the action of a supported cerium catalyst, carrying out alkylation reaction on 1, 1, 2, 3, 3, 5-hexamethylindane and epoxypropane, then carrying out dehydration condensation cyclization to generate galaxolide, and carrying out continuous rectification to separate the product. The problems of complex process, low raw material utilization rate, low safety and the like in the prior art are solved, the process is simple, the raw material conversion rate is greater than 95%, and the product selectivity is greater than 92%.

Micro-continuous flow technology for producing tonalide

The invention discloses a micro-continuous flow technology for producing tonalide. The technology taking 1,1,3,4,4,6-hexamethyltetrahydronaphthalene (HMT) and acetyl chloride as raw materials, anhydrous aluminum chloride as a catalyst and dichloroethane and other organic matters as a solvent comprises the following steps: mixing the anhydrous aluminum chloride, the solvent and acetyl chloride under a low-temperature condition to obtain a catalyst phase; mixing and dissolving the raw material HMT with the solvent to obtain a raw material phase; respectively pre-cooling the raw material phase and the catalyst phase, and introducing the pre-cooled raw material phase and catalyst phase into a micro-channel reactor, and performing a reaction; and finally, introducing the obtained reaction product into a microstructure mixing module, quenching and layering the obtained reaction product, and then carrying out extraction, rotary evaporation, recrystallization and drying to obtain the tonalide.The micro-continuous flow technology has the advantages of short retention time, continuousness in operation, increase of the production efficiency of the product, improvement of the production safety and the product yield by timely removing heat in the reaction process, and reduction of the risk of the quenching process by timely removing heat in the quenching process.

Synthetic process of galaxolide

The invention relates to a synthetic process of galaxolide. When an intermediate 1,1,2,3,3-pentamethylindane is prepared, macroporous strong-acidic styrenes cation exchanging resin prepared by the process is selected as a catalyst to react under a condition of no solvent, so that the pollution of waste gas, waste solids and waste water can be reduced, the solid catalysis is easy to separate, the industrialized production is facilitated, and the yield reaches up to 70 percent or more.