1222178-35-9

Basic information

• Product Name: (R)-1-(tert-butylamino)-3-(2-methoxyphenoxy)propan-2-ol
• Synonyms: (R)-1-(tert-butylamino)-3-(2-methoxyphenoxy)propan-2-ol
• CAS NO: 1222178-35-9
• Molecular Weight: 253.342
• Mol File: 1222178-35-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-1-(tert-butylamino)-3-(2-methoxyphenoxy)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(tert-butylamino)-3-(2-methoxyphenoxy)propan-2-ol(1222178-35-9)
• EPA Substance Registry System: (R)-1-(tert-butylamino)-3-(2-methoxyphenoxy)propan-2-ol(1222178-35-9)

Safety Data

• Hazardous Substances Data: 1222178-35-9(Hazardous Substances Data)

Upstream product

• 1222178-02-0 (S)-1-bromo-3-(2-meythoxyphenoxy)prop-2-yl acetate 
• 75-64-9 tert-butylamine 
• 2210-74-4 (R)-1,2-epoxy-3-(2-methoxyphenyloxy)-propane 

Relevant articles and documents

Enantioselective α-hydroxylation of β-keto esters catalyzed by chiral S-timolol derivatives

A screen of aryloxy aminopropanol organocatalysts derived from the β-blocker inhibitor S-timolol determined the most active catalyst of asymmetric α-hydroxylation of β-keto esters. (R)-1-(tert-butylamino)- 3-(3,4,5-trimethoxyphenoxy) propan-2-ol (3k) was the most effective derivative, enantioselectively catalyzing α-hydroxylation of β-keto esters using tert-butyl hydroperoxide as the oxidant in hexane to afford the corresponding products in excellent yield and with good enantioselectivity (up to 96% yield, 88% ee).