1222185-07-0

Basic information

• Product Name: methyl-4'-(4-(tert-butoxycarbonylamino)benzylcarbamoyl)-2,2'-bipyridine-4-carboxylate
• Synonyms: methyl-4'-(4-(tert-butoxycarbonylamino)benzylcarbamoyl)-2,2'-bipyridine-4-carboxylate
• CAS NO: 1222185-07-0
• Molecular Weight: 462.505
• Mol File: 1222185-07-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl-4'-(4-(tert-butoxycarbonylamino)benzylcarbamoyl)-2,2'-bipyridine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl-4'-(4-(tert-butoxycarbonylamino)benzylcarbamoyl)-2,2'-bipyridine-4-carboxylate(1222185-07-0)
• EPA Substance Registry System: methyl-4'-(4-(tert-butoxycarbonylamino)benzylcarbamoyl)-2,2'-bipyridine-4-carboxylate(1222185-07-0)

Safety Data

• Hazardous Substances Data: 1222185-07-0(Hazardous Substances Data)

Upstream product

• 71071-46-0 4,4'-bis(carbomethoxy)-2,2'-bipyridine 
• 6813-38-3 2,2'-Bipyridine-4,4'-dicarboxylic acid 
• 220298-96-4 4‐(tert‐butoxycarbonylamino)benzylamine 
• 161955-60-8 4'-(methoxycarbonyl)-[2,2'-bipyridine]-4-carboxylic acid 

Downstream Products

• 1222185-08-1 4'-(4-(tert-butoxycarbonylamino)benzylcarbamoyl)-2,2'-bipyridine-4-carboxylic acid 
• 1222184-65-7 4'-(4-aminobenzylcarbamoyl)-2,2'-bipyridine-4-carboxylic acid 

Relevant articles and documents

Inhibition of histone demethylases by 4-Carboxy-2,2'-Bipyridyl compounds

Exploiting epigenetics: 2-Oxoglutarate (2OG)-dependent histone lysine demethylases, such as JMJD2E, are potential therapeutic targets in a range of diseases. Through structure-activity relationship studies and analyses, we identified a potent 4-carboxy-2,2'-bipyridyl compound, which inhibits JMJD2E with an IC50 value of 110nM, representing a 66-fold improvement over the lead compound. These bipyridyl derivatives bind in the 2-oxoglutarate binding site.