71071-46-0Relevant articles and documents
Factors Impacting Electron Transfer in Cyano-Bridged {Fe2Co2} Clusters
Zheng, Chunyang,Xu, Juping,Yang, Zhixin,Tao, Jun,Li, Dongfeng
, p. 9687 - 9689 (2015)
A cyano-bridged {FeIII2CoII2} complex exhibits reversible thermally and photoinduced intramolecular charge transfer. Its desolvated, MeOH-d4, and other analogues were compared to disclose the impact factors on the electron-transfer behavior of these {FeIII2CoII2} clusters.
Hetero-Bis-Conjugation of Bioactive Molecules to Half-Sandwich Ruthenium(II) and Iridium(III) Complexes Provides Synergic Effects in Cancer Cell Cytotoxicity
Batchelor, Lucinda K.,Biancalana, Lorenzo,Brabec, Viktor,Degano, Ilaria,Dyson, Paul J.,Hadiji, Mouna,Kostrhunova, Hana,Marchetti, Fabio,Pampaloni, Guido,Zacchini, Stefano
, p. 9529 - 9541 (2021)
Four bipyridine-Type ligands variably derivatized with two bioactive groups (taken from ethacrynic acid, flurbiprofen, biotin, and benzylpenicillin) were prepared via sequential esterification steps from commercial 2,2′-bipyridine-4,4′-dicarboxylic acid and subsequently coordinated to ruthenium(II) p-cymene and iridium(III) pentamethylcyclopentadienyl scaffolds. The resulting complexes were isolated as nitrate salts in high yields and fully characterized by analytical and spectroscopic methods. NMR and MS studies in aqueous solution and in cell culture medium highlighted a substantial stability of ligand coordination and a slow release of the bioactive fragments in the latter case. The complexes were assessed for their antiproliferative activity on four cancer cell lines, showing cytotoxicity to the low micromolar level (equipotent with cisplatin). Additional biological experiments revealed a multimodal mechanism of action of the investigated compounds, involving DNA metalation and enzyme inhibition. Synergic effects provided by specific combinations of metal and bioactive fragments were identified, pointing toward an optimal ethacrynic acid/flurbiprofen combination for both Ru(II) and Ir(III) complexes.
Synthesis, biomacromolecular interactions, photodynamic no releasing and cellular imaging of two [rucl(Qn)(lbpy)(no)]x complexes
Bai, Hehe,Gong, Wenjun,Liu, Chenyang,Song, Luna,Wang, Ai,Wang, Hongfei,Wang, Li,Zhao, Xuan,Zhao, Yi
, (2021)
Two light-activated NO donors [RuCl(qn)(Lbpy)(NO)]X with 8-hydroxyquinoline (qn) and 2,2′-bipyridine derivatives (Lbpy) as co-ligands were synthesized (Lbpy1 = 4,4′-dicarboxyl-2,2′-dipyridine, X = Cl? and Lbpy2 = 4,4′-dimethoxycarbonyl-2,2′-dipyridine, X = NO3? ), and characterized using ultraviolet–visible (UV-vis) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, nuclear magnetic resonance (1 H NMR), elemental analysis and electrospray ionization mass spectrometry (ESI-MS) spectra. The [RuCl(qn)(Lbpy2 )(NO)]NO3 complex was crystallized and exhibited distorted octahedral geometry, in which the Ru–N(O) bond length was 1.752(6) ? and the Ru–N–O angle was 177.6(6)? . Time-resolved FT-IR and electron paramagnetic resonance (EPR) spectra were used to confirm the photoactivated NO release of the complexes. The binding constant (Kb ) of two complexes with human serum albumin (HSA) and DNA were quantitatively evaluated using fluorescence spectroscopy, Ru-Lbpy1 (Kb ~106 with HSA and ~104 with DNA) had higher affinity than Ru-Lbpy2 . The interactions between the complexes and HSA were investigated using matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF-MS) and EPR spectra. HSA can be used as a carrier to facilitate the release of NO from the complexes upon photoirradiation. The confocal imaging of photo-induced NO release in living cells was successfully observed with a fluorescent NO probe. Moreover, the photocleavage of pBR322 DNA for the complexes and the effect of different Lbpy substituted groups in the complexes on their reactivity were analyzed.
Synthesis of novel tridentate pyrazole–bipyridine ligands for Co-complexes as redox-couples in dye-sensitized solar cells
Zavozin, Alexander G.,Ignat'ev, Nikolai V.,Schulte, Michael,Zlotin, Sergei G.
, p. 8551 - 8556 (2015)
Novel pyrazole bipyridine ligands have been synthesized from 4,4′-substituted bipyridines through oxidation, chlorination and non-catalyzed C–N coupling of potassium pyrazolate with 6-halogen-4,4′-bipyridines in diglyme. These tridentate pyrazole–bipyridine ligands are of interest as components of new redox systems for dye-sensitized solar cells.
A Systematic Study of the Effects of Complex Structure on Aryl Iodide Oxidative Addition at Bipyridyl-Ligated Gold(I) Centers
Bower, John F.,Cadge, Jamie A.,Russell, Christopher A.
supporting information, p. 24976 - 24983 (2021/10/20)
A combined theoretical and experimental approach has been used to study the unusual mechanism of oxidative addition of aryl iodides to [bipyAu(C2H4)]+ complexes. The modular nature of this system allowed a systematic assessment of the effects of complex structure. Computational comparisons between cationic gold and the isolobal (neutral) Pd0 and Pt0 complexes revealed similar mechanistic features, but with oxidative addition being significantly favored for the group 10 metals. Further differences between Au and Pd were seen in experimental studies: studying reaction rates as a function of electronic and steric properties showed that ligands bearing more electron-poor functionality increase the rate of oxidative addition; in a complementary way, electron-rich aryl iodides give faster rates. This divergence in mechanism compared to Pd suggests that Ar?X oxidative addition with Au can underpin a broad range of new or complementary transformations.
