122223-38-5

Upstream product

• 122235-59-0 methyl 3(RS),5(SR)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate 
• 5153-69-5 4-fluoro-β-nitrostyrene 
• 124401-37-2 N,N-bis<3-(4-fluorophenyl)-4-(methoxycarbonyl)-5-methyl-2,3-dihydrofuran-2-yl>hydroxylamine 
• 122485-75-0 methyl 5(RS)-hydroxy-3-oxo-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate 
• 122223-68-1 1-isopropyl-2-methyl-3-(methoxycarbonyl)-4-(4-fluorophenyl)-1H-pyrrole 
• 122223-69-2 1-isopropyl-2-methyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole 
• 122223-70-5 1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrole-3-carboxaldehyde 

Relevant academic research and scientific papers

Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 2. Derivatives of 7-(1H-Pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) Acids

A series of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoates (-heptanoates) 1 and 2 have been prepared and tested for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.The most potent compounds exceeded mevinolin's activity in vitro and in vivo.