1222343-69-2

Basic information

• Product Name: C₁₉H₁₉N₃O₂S
• CAS NO: 1222343-69-2
• Molecular Weight: 353.445
• Mol File: 1222343-69-2.mol

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₉N₃O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₉N₃O₂S(1222343-69-2)
• EPA Substance Registry System: C₁₉H₁₉N₃O₂S(1222343-69-2)

Safety Data

• Hazardous Substances Data: 1222343-69-2(Hazardous Substances Data)

Upstream product

• 1520-27-0 1-(4-hydroxyphenyl)thiourea 
• 210832-85-2 2-bromo-1-(4-(piperidin-1-yl)-phenyl)ethan-1-one 

Relevant articles and documents

2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97)

Valosin-containing protein (VCP; also known as p97) is a member of the AAA ATPase family with a central role in the ubiquitin-degradation of misfolded proteins. VCP also exhibits antiapoptotic function and metastasis via activation of nuclear factor kappa-B signaling pathway. We have discovered that 2-anilino-4-aryl-1,3-thiazoles are potent drug-like inhibitors of this enzyme. The identified compounds show low nanomolar VCP potency, demonstrate SAR trends, and show activity in a mechanism based cellular assay. This series of compounds represents the first steps towards a novel, small molecule VCP inhibitor as a cancer therapeutic.