122246-98-4

Upstream product

• 103654-98-4 2,2-Dichloro-1-(2-chloro-phenyl)-3,3,3-trifluoro-propan-1-ol 
• 354-58-5 1,1,1-Trichloro-2,2,2-trifluoroethane 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 122247-01-2 1-chloro-2-(3,3,3-trifluoroprop-1-yn-1-yl)benzene 
• 1233881-89-4 2-(trifluoromethyl)-1-[4-(trifluoromethyl)phenyl]-1H-indole 
• 1233881-83-8 1-(2-tolyl)-2-(trifluoromethyl)-1H-indole 
• 1233881-86-1 1-(4-fluorophenyl)-2-(trifluoromethyl)-1H-indole 
• 1448458-42-1 2-phenyl-4-(trifluoromethyl)benzo[b]oxepine 
• 1448458-52-3 2-(4-nitrophenyl)-4-(trifluoromethyl)benzo[b]oxepine 
• 1448458-53-4 4-(4-(trifluoromethyl)benzo[b]oxepin-2-yl)benzonitrile 
• 1448458-43-2 2-(p-tolyl)-4-(trifluoromethyl)benzo[b]oxepine 
• 122247-09-0 5-(2-Chloro-phenyl)-3-(2,6-dichloro-phenyl)-4-trifluoromethyl-isoxazole 
• 122247-16-9 4-(2-Chloro-phenyl)-3-(2,6-dichloro-phenyl)-5-trifluoromethyl-isoxazole 
• 122246-96-2 3-(4-Chloro-phenyl)-5-(2-chloro-phenyl)-4-trifluoromethyl-isoxazole 
• 122246-97-3 3-(4-Chloro-phenyl)-4-(2-chloro-phenyl)-5-trifluoromethyl-isoxazole 
• 141543-48-8 5-(2-Chloro-phenyl)-1-(2,6-dichloro-phenyl)-4-trifluoromethyl-1H-[1,2,3]triazole 
• 141543-56-8 4-(2-Chloro-phenyl)-1-(2,6-dichloro-phenyl)-5-trifluoromethyl-1H-[1,2,3]triazole 

Relevant academic research and scientific papers

Copper-catalyzed thiolation annulations of 1,4-dihalides with sulfides leading to 2-trifluoromethyl benzothiophenes and benzothiazoles

Copper-catalyzed double thiolation reaction of 1,4-dihalides with sulfides has been developed for selectively synthesizing 2-trifluoromethyl benzothiophenes and benzothiazoles. In the presence of CuI, a variety of 2-halo-1-(2-haloaryl)-3,3,3-trifluoropropylenes smoothly underwent the thiolation annulation with Na2S to afford 2-trifluoromethyl benzothiophenes in moderate to good yields. Moreover, the conditions are compatible with N-(2-haloaryl)trifluoroacetimidoyl chlorides in the presence of NaHS and K3PO4, leading to 2-trifluoromethyl benzothiazoles.

Synthesis of 1-Aryl-3,3,3-trifluoro-1-propynes and 3,5-Diaryl-4-trifluoromethylisoxazoles

Diaryl-substituted trifluoromethylisoxazoles 5a-i, 6a-c, and 6e-i are synthesized from aromatic nitrile oxides and various substituted 1-aryl-3,3,3-trifluoro-1-propynes.