1448458-52-3

Upstream product

• 122246-98-4 2-chloro-1-(2-bromophenyl)-3,3,3-trifluoroprop-1-ene 
• 100-19-6 (4-nitrophenyl)ethanone 
• 1188436-17-0 1-bromo-2-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)benzene 

Relevant academic research and scientific papers

Copper-catalyzed tandem C-C/C-O bond-forming reactions of ortho-halo-β-chlorostyrenes with ketones: Synthesis of 4- trifluoromethylbenzoxepines

A copper-catalyzed cyclization reaction of trifluoromethyl-containing ortho-halo-β-chlorostyrenes with ketones has been developed. Using a combination of copper(I) bromide, 2,2,6,6-tetramethylheptane-3,5-dione and sodium tert-butoxide, a variety of 4-trifluoromethylbenzoxepines was prepared in moderate to good yields by the tandem a-alkenylation of ketones with subsequent O-arylation.