1222467-25-5Relevant academic research and scientific papers
Benzylidene acetal type bridged nucleic acids: Changes in properties upon cleavage of the bridge triggered by external stimuli
Morihiro, Kunihiko,Kodama, Tetsuya,Obika, Satoshi
scheme or table, p. 7918 - 7926 (2011/09/12)
Four classes of benzylidene acetal type bridged nucleic acids (BA-BNAs) were designed with 2′,4′-bridged structures that cleaved upon exposure to appropriate external stimuli. Cleavage of 6-nitroveratrylidene and 2-nitrobenzylidene acetal type BNA bridges
Effect of 3′-end capping of aptamer with various 2′,4′-bridged nucleotides: Enzymatic post-modification toward a practical use of polyclonal aptamers
Kasahara, Yuuya,Kitadume, Shunsuke,Morihiro, Kunihiko,Kuwahara, Masayasu,Ozaki, Hiroaki,Sawai, Hiroaki,Imanishi, Takeshi,Obika, Satoshi
supporting information; experimental part, p. 1626 - 1629 (2010/08/06)
The capping of the 3′-ends of thrombin binding aptamers (TBAs) with bridged nucleotides increased the nuclease resistances and the stabilities in human serum. The binding abilities of the aptamers were not affected by the capping. The capping could be simply executed via a one step enzymatic process using 2′,4′-bridged nucleoside 5′-triphosphate and terminal deoxynucleotidyl transferase.
