1222490-34-7 Usage
Description
SGD 1882 is a potent and selective inhibitor of the nuclear export protein exportin-1 (XPO1), a chemical compound with demonstrated anti-cancer properties. It functions by preventing the export of tumor suppressor proteins from the nucleus, which results in the accumulation of these proteins and the subsequent inhibition of tumor growth. This mechanism of action positions SGD 1882 as a promising candidate for targeted cancer therapy.
Uses
Used in Oncology:
SGD 1882 is used as an anti-cancer agent for its ability to inhibit the nuclear export of tumor suppressor proteins, thereby promoting their accumulation in the nucleus and contributing to the suppression of tumor growth. It has been studied for its potential in treating various types of cancer, including both solid tumors and hematological malignancies.
Used in Targeted Cancer Therapy:
In the field of targeted cancer therapy, SGD 1882 is utilized as a selective inhibitor of XPO1, a protein crucial for the nuclear export of tumor suppressor proteins. By inhibiting this process, SGD 1882 enhances the intranuclear concentration of these proteins, making it a valuable tool in the development of cancer treatment strategies that are more precise and potentially less harmful than traditional chemotherapy.
Used in Preclinical and Clinical Cancer Research:
SGD 1882 is employed in preclinical and clinical studies to evaluate its efficacy and safety in cancer treatment. These studies are essential for understanding the compound's potential as a therapeutic agent and for determining the optimal conditions for its use in treating cancer patients.
Check Digit Verification of cas no
The CAS Registry Mumber 1222490-34-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,2,4,9 and 0 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1222490-34:
(9*1)+(8*2)+(7*2)+(6*2)+(5*4)+(4*9)+(3*0)+(2*3)+(1*4)=117
117 % 10 = 7
So 1222490-34-7 is a valid CAS Registry Number.
1222490-34-7Relevant articles and documents
Synthesis of a C2-aryl-pyrrolo[2,1-c][1,4]benzodiazepine monomer enabling the convergent construction of symmetrical and non-symmetrical dimeric analogs
Kolakowski, Robert V.,Young, Thomas D.,Howard, Philip W.,Jeffrey, Scott C.,Senter, Peter D.
, p. 4512 - 4515 (2015)
Abstract We disclose the synthesis of a versatile C2-aryl-pyrrolo[2,1-c][1,4]benzodiazepine (PBD) monomer that enables the late-stage diversification and synthesis of PBD dimers. The monomer unit was elaborated and dimerized utilizing different tethers to yield symmetric and non-symmetrical C2-aryl-PBD dimers. The dimers were tested for cytotoxic activity on a number of cancer cell lines and showed potent cytotoxicity in the nanomolar to picomolar range. The synthesis of PBD monomers enables the modular construction of PBD free drugs and drug-linkers that may have application for the development of antibody-drug conjugations.
