122273-82-9

Upstream product

• 130688-86-7 (3E)-2,3-dihydro-3-[(3,4-dimethoxyphenyl)methylene]-4H-1-benzopyran-4-one 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 29682-12-0 1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone 
• 89367-09-9 3’,4’-dimethoxyhomoisoflavone 
• 86383-39-3 3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)propan-1-one 

Relevant academic research and scientific papers

Synthesis and biological activity of (±)-7,3′,4′-trihydroxyhomoisoflavan and its analogs

Acetylcholinesterase (AChE) inhibitors and neurite outgrowth promoters are thought to alleviate the symptoms of degenerative brain disorders, such as Alzheimer's disease. We designed and synthesized a series of homoisoflavonoids based on the structure of natural homoisoflavan isolated from Dracaena cambodiana dragon's blood. The homoisoflavonoids were then evaluated as AChE inhibitors and neurite outgrowth promoters. The catechol structure of the homoisoflavan B rings was important for AChE inhibition, and some of the homoisoflavonoids significantly promoted neurite outgrowth induced by nerve growth factor (NGF).

Reduction par les hydrures : synthese et stereochimie des benzyl-3 chromannols-4

Reduction of 3-arylidene 4-chromannones with lithium aluminium hydride leads in straightforward fashion to two 3-arylmethyl 4-chromannols diastereoisomers, for each derivative.Stereochemistry of 3-benzyl 4-chromanols is resolved by 1H and 13C NMR.Major trans compounds were obtained.