86383-39-3

Usage

Uses

Used in Cancer Research:
1-Propanone, 3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)is used as a degradation tag in the study of cancer research. It has been found to effectively deplete FKBP12F36V-MELK(sg3R), a protein involved in cancer cell proliferation and survival, making it a promising candidate for further research and potential therapeutic applications in cancer treatment.

Upstream product

• 19152-36-4 (E)-2'-hydroxy-3,4-dimethoxychalcone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 79140-20-8 2'-hydroxy-3,4-dimethoxychalcone 
• 118-93-4 o-hydroxyacetophenone 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 

Downstream Products

• 875467-89-3 (+/-)-3-(3',4'-dimethoxybenzyl)-3-hydroxymethyl-2,3-dihydro-4H-1-benzopyran-4-one 
• 89367-09-9 3’,4’-dimethoxyhomoisoflavone 
• 84289-41-8 3',4'-dimethoxy-3-benzyl-4-chromanone 
• 6344-21-4 3',4'-dimethoxyflavanone 
• 4143-62-8 3',4'-dimethoxyflavone 

Relevant academic research and scientific papers

Synthesis, anticancer, structural, and computational docking studies of 3-benzylchroman-4-one derivatives

A series of 3-Benzylchroman-4-ones were synthesized and screened for anticancer activity by MTT assay. The compounds were evaluated against two cancerous cell lines BT549 (human breast carcinoma), HeLa (human cervical carcinoma), and one noncancerous cell

Iridium catalyzed alkylation of 2′-hydroxyacetophenone with alcohols under thermal or microwave conditions

2′-Hydroxyacetophenone was alkylated with a range of substituted benzyl and heteroaryl alcohols to afford the corresponding C-alkylated products in good yields under microwave irradiation. The C-alkylated products were reacted with bromoacetonitrile to afford 2-amino-3-benzyl 1,4-naphthoquinone derivatives in moderate yields.

Candida rugosa lipase-mediated enantioselective acetylation studies on (±)-3-arylmethyl-3-hydroxymethyl-2,3-dihydro-1-benzopyran-4(H)-ones

Candida rugosa lipase, catalyzed enantioselective acetylation reactions have been performed on novel (±)-3-arylmethyl-3-hydroxymethyl-2,3- dihydrobenzopyran-4-ones in diisopropyl ether. The Candida rugosa lipase-catalyzed acetylations exhibit the enantiomeric separation of the racemic compounds 5a-g, the enantioselectivity of the reaction has been found to be highly dependent on the structure of the substrate. The enantiomeric excess (ee) values are determined by 1H NMR spectral analysis of their O-acetylmandelic acid esters and highest enantiomeric excess obtained is 79% in case of 5c.

Facile reduction of chalcones to dihydrochalcones with NaBH4/Ni2+ system

Chalcones have been found to undergo facile reduction on treatment with sodium borohydride-nickel chloride system in dioxan-methanol medium to afford dihydrochalcones.

Synthesis and angioprotective, antiallergic and antihistaminic activities of 3-benzyl-chromones (homoisoflavones)

Various 3-benzyl-chromones were prepared and their angioprotective antiallergic and antihistaminic activities were studied. - 3-benzyl-chromones / antiallergic / antihistaminic / angioprotective