1222765-97-0Relevant academic research and scientific papers
Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein
Al-Ramahi, Ismael,Giridharan, Sai Srinivas Panapakkam,Chen, Yu-Chi,Patnaik, Samarjit,Safren, Nathaniel,Hasegawa, Junya,de Haro, Maria,Gee, Amanda K. Wagner,Titus, Steven A.,Jeong, Hyunkyung,Clarke, Jonathan,Krainc, Dimitri,Zheng, Wei,Irvine, Robin F.,Barmada, Sami,Ferrer, Marc,Southall, Noel,Weisman, Lois S.,Botas, Juan,Marugan, Juan Jose
, (2018/01/27)
The discovery of the causative gene for Huntington’s disease (HD) has promoted numerous efforts to uncover cellular pathways that lower levels of mutant huntingtin protein (mHtt) and potentially forestall the appearance of HD-related neurological defects.
COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF TREATING OR PREVENTING NEURODEGENERATIVE DISEASES OR DISORDERS
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Page/Page column 50, (2012/04/17)
Disclosed are compounds of the formula (I): wherein R1, R2, X, Y, and Z as described herein, or pharmaceutically acceptable salts thereof, for use in treating or preventing neurodegenerative diseases and disorders such as Huntington'
