1222801-82-2Relevant academic research and scientific papers
Synthesis and anticancer activity of indolin-2-one derivatives bearing the 4-thiazolidinone moiety
Wang, Shuobing,Zhao, Yanfang,Zhu, Wufu,Liu, Ying,Guo, Kaixing,Gong, Ping
, p. 73 - 80 (2012)
A novel series of indolin-2-one derivatives containing the 4-thiazolidinone moiety (5a-5p) was synthesized and the cytotoxicity of these derivatives was evaluated in vitro against three human cancer cell lines (HT-29, H460 and MDA-MB-231) by standard MTT assay. Some prepared compounds exhibited significant cytotoxicity against different human cancer cell lines. Several potent compounds were further evaluated against one normal cell line (WI-38). In particular, the promising compound 5h showed remarkable cytotoxicity and selectivity against the HT-29 and H460 cancer cell lines (IC50 = 0.016 μmol/L, 0.0037 μmol/L, respectively). A novel series of indolin-2-one derivatives containing the 4-thiazolidinone moiety (5a-5p) was synthesized and evaluated in vitro against three human cancer cell lines (HT-29, H460 and MDA-MB-231). The promising compound 5h showed remarkable cytotoxicity and selectivity against HT-29 and H460 cancer cell lines (IC50 = 0.016 μmol/L, 0.0037 μmol/L, respectively) Copyright
Synthesis and biological evaluation of 5-benzylidenerhodanine-3-acetic acid derivatives as AChE and 15-LOX inhibitors
Shafii, Negah,Khoobi, Mehdi,Amini, Mohsen,Sakhteman, Amirhossein,Nadri, Hamid,Moradi, Alireza,Emami, Saeed,Saeedian Moghadam, Ebrahim,Foroumadi, Alireza,Shafiee, Abbas
, p. 389 - 395 (2015/07/27)
A series of 5-benzylidenerhodanine-3-acetamides bearing morpholino-, 4-arylpiperazinyl-, or 4-benzylpiperidinyl- moieties were synthesized and their inhibitory activities against acetylcholinesterase (AChE) were evaluated. Alteration of amide part and substitution on the benzylidene moiety resulted in change of anti-AChE activity. The most active compound was the 1-benzylpiperidinyl derivative containing 4-(dimethylamino)benzylidene scaffold. Notably, the intermediate compounds, namely 5-arylidene-rhodanine-3-acetic acids (3), showed mild inhibitory activity against 15-lipoxygenase (15-LOX), while the final compound 4 showed no activity against 15-LOX.
Synthesis and antibacterial activity of 5-ylidenethiazolidin-4-ones and 5-benzylidene-4,6-pyrimidinediones
Toma?i?, Tihomir,Zidar, Nace,Mueller-Premru, Manica,Kikelj, Danijel,Ma?i?, Lucija Peterlin
experimental part, p. 1667 - 1672 (2010/05/18)
5-Benzylidenethiazolidin-4-ones and 5-benzylidenepyrimidine-4,6-diones (compounds 1-9), carrying 2,3,4-trifluoro or 3,4,5-trimethoxy groups on the benzylidene moiety, and rhodanine derivatives 10 and 11 were synthesized and assayed in vitro for their anti
