122289-05-8Relevant academic research and scientific papers
5'-vinylhalo-aristeromycin/adenosine analogs and immunosuppressants
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, (2008/06/13)
The present invention relates to a method of effecting immunosuppression in a patient in need thereof comprising administering to said patient an effective immunosuppressive amount of certain 5'-vinylhalo-aristeromycin/adenosine analogs.
4',5'-Unsaturated 5'-Halogenated Nucleosides. Mechanism-Based and Competitive Inhibitors of S-Adenosyl-L-homocysteine Hydrolase
Jarvi, Esa T.,McCarthy, James R.,Mehdi, Shujaath,Matthews, Donald P.,Edwards, Michael L.,et al.
, p. 647 - 656 (2007/10/02)
The design and synthesis of (E)- and (Z)-5'-fluoro-4',5'-didehydro-5'-deoxyadenosine (6 and 13, respectively), a new class of mechanism-based inhibitors of S-adenosyl-L-homocysteine (SAH) hydrolase, is described.A number of analogues of 6 and 13 were synt
5'-deoxy-4',5'-unsaturated-5'-substituted adenosines
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, (2008/06/13)
This invention relates to certain aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.
