133191-02-3Relevant articles and documents
4',5'-Unsaturated 5'-Halogenated Nucleosides. Mechanism-Based and Competitive Inhibitors of S-Adenosyl-L-homocysteine Hydrolase
Jarvi, Esa T.,McCarthy, James R.,Mehdi, Shujaath,Matthews, Donald P.,Edwards, Michael L.,et al.
, p. 647 - 656 (2007/10/02)
The design and synthesis of (E)- and (Z)-5'-fluoro-4',5'-didehydro-5'-deoxyadenosine (6 and 13, respectively), a new class of mechanism-based inhibitors of S-adenosyl-L-homocysteine (SAH) hydrolase, is described.A number of analogues of 6 and 13 were synt