1222891-33-9

Basic information

• Product Name: 5,6-dimethyl-1-tosyl-1H-benzo[d]imidazol-2-amine
• CAS NO: 1222891-33-9
• Molecular Weight: 315.396
• Mol File: 1222891-33-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,6-dimethyl-1-tosyl-1H-benzo[d]imidazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-dimethyl-1-tosyl-1H-benzo[d]imidazol-2-amine(1222891-33-9)
• EPA Substance Registry System: 5,6-dimethyl-1-tosyl-1H-benzo[d]imidazol-2-amine(1222891-33-9)

Safety Data

• Hazardous Substances Data: 1222891-33-9(Hazardous Substances Data)

Upstream product

• 29096-75-1 2-amino-5,6-dimethylbenzimidazole 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

Identification of inhibitors of NOD1-induced nuclear factor-κB activation

NOD1 (nucleotide-binding oligomerization domain 1) protein is a member of the NLR (NACHT and leucine rich repeat domain containing proteins) protein family, which plays a key role in innate immunity as a sensor of specific microbial components derived from bacterial peptidoglycans and induction of inflammatory responses. Mutations in NOD proteins have been associated with various inflammatory diseases that affect NF-κB (nuclear factor κB) activity, a major signaling pathway involved in apoptosis, inflammation, and immune response. A luciferase-based reporter gene assay was utilized in a high-throughput screening program conducted under the NIH-sponsored Molecular Libraries Probe Production Center Network program to identify the active scaffolds. Herein, we report the chemical synthesis, structure-activity relationship studies, downstream counterscreens, secondary assay data, and pharmacological profiling of the 2-aminobenzimidazole lead (compound 1c, ML130) as a potent and selective inhibitor of NOD1-induced NF-κB activation.